Highlights & Basics
- Salmonellosis is a very common cause of gastroenteritis in the developed world and invasive disease in the developing world.
- Salmonella enterica causes both sporadic infections and outbreaks of disease.
- Almost any food product can be contaminated, but outbreaks are most commonly due to poultry, dairy items such as raw milk, and undercooked eggs. Outbreaks associated with ingestion of peanut products and raw produce such as sprouts have been described. Reptile exposure also has been associated with the development of the disease.
- The clinical presentation is most commonly a self-limited gastroenteritis.
- Diagnosis relies on isolation of the organism from stool cultures or by detection of pathogen-specific nucleic acid.
Quick Reference
History & Exam
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Definition
Epidemiology
Etiology
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Citations
Delahoy MJ, Shah HJ, Weller DL, et al. Preliminary incidence and trends of infections caused by pathogens transmitted commonly through food - foodborne diseases active surveillance network, 10 U.S. sites, 2022. MMWR Morb Mortal Wkly Rep. 2023 Jun 30;72(26):701-6.[Abstract][Full Text]
Pegues DA, Miller SI. Salmonella species, including Salmonella Typhi. In: Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 7th ed. Philadelphia, PA: Churchill Livingstone; 2010:2887-903.
Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis. 2017 Nov 29;65(12):1963-73.[Abstract][Full Text]
Riddle MS, DuPont HL, Connor BA. ACG Clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016 May;111(5):602-22.[Abstract]
1. Kauffman F. The diagnosis of Salmonella types. Springfield, IL: Charles C Thomas; 1950.
2. Centers for Disease Control and Prevention. National enteric disease surveillance: Salmonella surveillance overview. Jul 2011 [internet publication].[Full Text]
3. Brenner FW, Villar RG, Angulo FJ, et al. Salmonella nomenclature. J Clin Microbiol. 2000 Jul;38(7):2465-7.[Full Text]
4. Voetsch AC, Van Gilder TJ, Angulo FJ, et al. FoodNet estimate of the burden of illness caused by nontyphoidal Salmonella infections in the United States. Clin Infect Dis. 2004 Apr 15;38 Suppl 3:S127-34.[Abstract][Full Text]
5. Mead PS, Slutsker L, Dietz V, et al. Food-related illness and death in the United States. Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25.[Abstract][Full Text]
6. Scallan E, Hoekstra RM, Angulo FJ, et al. Foodborne illness acquired in the United States - major pathogens. Emerg Infect Dis. 2011 Jan;17(1):7-15.[Abstract]
7. Spina A, Kerr KG, Cormican M, et al. Spectrum of enteropathogens detected by the FilmArray GI panel in a multicentre study of community-acquired gastroenteritis. Clin Microbiol Infect. 2015 Aug;21(8):719-28.[Abstract][Full Text]
8. European Centre for Disease Prevention and Control. Salmonellosis - annual epidemiological report for 2021.Dec 2022 [internet publication].[Full Text]
9. Delahoy MJ, Shah HJ, Weller DL, et al. Preliminary incidence and trends of infections caused by pathogens transmitted commonly through food - foodborne diseases active surveillance network, 10 U.S. sites, 2022. MMWR Morb Mortal Wkly Rep. 2023 Jun 30;72(26):701-6.[Abstract][Full Text]
10. Moon RC, Bleak TC, Rosenthal NA, et al. Epidemiology and economic burden of acute infectious gastroenteritis among adults treated in outpatient settings in US health systems. Am J Gastroenterol. 2023 Jun 1;118(6):1069-79.[Abstract][Full Text]
11. Centers for Disease Control and Prevention. Salmonella. Nov 2023 [internet publication].[Full Text]
12. Greig JD, Lee MB. Enteric outbreaks in long-term care facilities and recommendations for prevention: a review. Epidemiol Infect. 2009 Feb;137(2):145-55.[Abstract]
13. Painter JA, Hoekstra RM, Ayers T, et al. Attribution of foodborne illnesses, hospitalizations, and deaths to food commodities by using outbreak data, United States, 1998-2008. Emerg Infect Dis. 2013 Mar;19(3):407-15.[Abstract][Full Text]
14. Collins JP, Shah HJ, Weller DL, et al. Preliminary incidence and trends of infections caused by pathogens transmitted commonly through food - foodborne diseases active surveillance network, 10 U.S. sites, 2016-2021. MMWR Morb Mortal Wkly Rep. 2022 Oct 7;71(40):1260-4.[Abstract][Full Text]
15. Barton Behravesh C, Mody RK, Jungk J, et al. 2008 outbreak of Salmonella Saintpaul infections associated with raw produce. N Engl J Med. 2011 Mar 10;364(10):918-27.[Abstract][Full Text]
16. Centers for Disease Control and Prevention. CDC investigation notice: Salmonella outbreak linked to ground beef. Aug 2023 [internet publication].[Full Text]
17. Centers for Disease Control and Prevention. Salmonella: salmonella outbreaks linked to backyard poultry. Nov 2022 [internet publication].[Full Text]
18. Adkins HJ, Escamilla J, Santiago LT, et al. Two-year survey of etiologic agents of diarrheal disease at San Lazaro Hospital, Manila, Republic of the Philippines. J Clin Microbiol. 1987 Jul;25(7):1143-7.[Abstract][Full Text]
19. Saidi SM, Iijima Y, Sang WK, et al. Epidemiological study on infectious diarrheal diseases in children in a coastal rural area of Kenya. Microbiol Immunol. 1997;41(10):773-8.[Abstract]
20. Morpeth SC, Ramadhani HO, Crump JA. Invasive non-Typhi Salmonella disease in Africa. Clin Infect Dis. 2009 Aug 15;49(4):606-11.[Abstract][Full Text]
21. Majowicz SE, Musto J, Scallan E, et al. The global burden of nontyphoidal Salmonella gastroenteritis. Clin Infect Dis. 2010 Mar 15;50(6):882-9.[Abstract][Full Text]
22. GBD 2019 Antimicrobial Resistance Collaborators. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022 Dec 17;400(10369):2221-48.[Abstract][Full Text]
23. Gordon MA. Invasive nontyphoidal Salmonella disease: epidemiology, pathogenesis and diagnosis. Curr Opin Infect Dis. 2011 Oct;24(5):484-9.[Abstract]
24. Kingsley RA, Msefula CL, Thomson NR, et al. Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res. 2009 Dec;19(12):2279-87.[Abstract][Full Text]
25. Okoro CK, Kingsley RA, Connor TR, et al. Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nat Genet. 2012 Nov;44(11):1215-21.[Abstract][Full Text]
26. Feasey NA, Hadfield J, Keddy KH, et al. Erratum: distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nat Genet. 2017 Mar 30;49(4):651.
27. Feasey NA, Dougan G, Kingsley RA, et al. Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa. Lancet. 2012 Jun 30;379(9835):2489-99.[Abstract][Full Text]
28. Singletary LA, Karlinsey JE, Libby SJ, et al. Loss of multicellular behavior in epidemic African nontyphoidal Salmonella enterica Serovar Typhimurium ST313 strain D23580. mBio. 2016 Mar 1;7(2):e02265.[Abstract][Full Text]
29. Koolman L, Prakash R, Diness Y, et al. Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission. PLoS Negl Trop Dis. 2022 Dec;16(12):e0010982.[Abstract][Full Text]
30. Gascón J. Epidemiology, etiology, and pathophysiology of traveler's diarrhea. Digestion. 2006 Feb;73 Suppl 1:102-8.[Abstract]
31. Corrado ML, DuPont HL, Cooperstock M, et al. Evaluation of new anti-infective drugs for the treatment of chronic carriage of Salmonella. Infectious Diseases Society of America and the Food and Drug Administration. Clin Infect Dis. 1992 Nov;15 Suppl 1:S259-62.[Abstract]
32. Crum-Cianflone NF. Salmonellosis and the gastrointestinal tract: more than just peanut butter. Curr Gastroenterol Rep. 2008 Aug;10(4):424-31.[Abstract][Full Text]
33. Gal-Mor O. Persistent infection and long-term carriage of typhoidal and nontyphoidal Salmonellae. Clin Microbiol Rev. 2018 Nov 28;32(1):e00088-18.[Abstract][Full Text]
34. Fierer J, Swancutt M. Non-typhoid Salmonella: a review. Curr Clin Top Infect Dis. 2000;20:134-57.[Abstract]
35. Blaser MJ, Newman LS. A review of human salmonellosis: I. infective dose. Rev Infect Dis. Nov-Dec 1982;4(6):1096-106.[Abstract]
36. Hennessy TW, Hedberg CW, Slutsker L, et al. A national outbreak of Salmonella enteritidis infections from ice cream. The investigation team. N Engl J Med. 1996 May 16;334(20):1281-6.[Abstract][Full Text]
37. Mintz ED, Cartter ML, Hadler JL, et al. Dose-response effects in an outbreak of Salmonella enteritidis. Epidemiol Infect. 1994 Feb;112(1):13-23.[Abstract]
38. Giannella RA, Broitman SA, Zamcheck N. Salmonella enteritis. I. Role of reduced gastric secretion in pathogenesis. Am J Dig Dis. 1971 Nov;16(11):1000-6.[Abstract]
39. Cook GC. Infective gastroenteritis and its relationship to reduced gastric acidity. Scand J Gastroenterol Suppl. 1985;111:17-23.[Abstract]
40. Centers for Disease Control and Prevention (CDC). Notes from the field: Salmonella Bredeney infections linked to a brand of peanut butter--United States, 2012. MMWR Morb Mortal Wkly Rep. 2013 Feb 15;62(6):107.[Abstract][Full Text]
41. Shimoni Z, Pitlik S, Leibovici L, et al. Nontyphoid Salmonella bacteremia: age-related differences in clinical presentation, bacteriology, and outcome. Clin Infect Dis. 1999 Apr;28(4):822-7.[Abstract]
42. Huang CF, Chen PL, Liu MF, et al. Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases. J Microbiol Immunol Infect. 2012 Oct;45(5):350-5.[Abstract]
43. Hohmann EL. Nontyphoidal salmonellosis. Clin Infect Dis. 2001 Jan 15;32(2):263-9.[Abstract][Full Text]
44. Pegues DA, Miller SI. Salmonella species, including Salmonella Typhi. In: Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 7th ed. Philadelphia, PA: Churchill Livingstone; 2010:2887-903.
45. Celum CL, Chaisson RE, Rutherford GW, et al. Incidence of salmonellosis in patients with AIDS. J Infect Dis. 1987 Dec;156(6):998-1002.[Abstract]
46. Gordon MA. Salmonella infections in immunocompromised adults. J Infect. 2008 Jun;56(6):413-22.[Abstract]
47. Peña-Sagredo JL, Fariñas MC, Perez-Zafrilla B, et al. Non-typhi Salmonella infection in patients with rheumatic diseases on TNF-alpha antagonist therapy. Clin Exp Rheumatol. Nov-Dec 2009;27(6):920-5.[Abstract]
48. Dykhuizen RS, Frazer R, Duncan C, et al. Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense. Antimicrob Agents Chemother. 1996 Jun;40(6):1422-5.[Abstract][Full Text]
49. Croswell A, Amir E, Teggatz P, et al. Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection. Infect Immun. 2009 Jul;77(7):2741-53.[Abstract][Full Text]
50. Pavia AT, Shipman LD, Wells JG, et al. Epidemiologic evidence that prior antimicrobial exposure decreases resistance to infection by antimicrobial-sensitive Salmonella. J Infect Dis. 1990 Feb;161(2):255-60.[Abstract]
51. Molbak K. Human health consequences of antimicrobial drug-resistant Salmonella and other foodborne pathogens. Clin Infect Dis. 2005 Dec 1;41(11):1613-20.[Abstract][Full Text]
52. Ryan CA, Nickels MK, Hargrett-Bean NT, et al. Massive outbreak of antimicrobial-resistant salmonellosis traced to pasteurized milk. JAMA. 1987 Dec 11;258(22):3269-74.[Abstract]
53. Mouy R, Fischer A, Vilmer E, et al. Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr. 1989 Apr;114(4 Pt 1):555-60.[Abstract]
54. Kaye D, Gill FA, Hook EW. Factors influencing host resistance to Salmonella infections: the effects of hemolysis and erythrophagocytosis. Am J Med Sci. 1967 Aug;254(2):205-15.[Abstract]
55. Sheen JM, Lin FJ, Yang YH, et al. Increased non-typhoidal Salmonella hospitalizations in transfusion-naïve thalassemia children: a nationwide population-based cohort study. Pediatr Res. 2022 Jun;91(7):1858-63.[Abstract][Full Text]
56. Guery R, Habibi A, Arlet JB, et al. Severe, non specific symptoms in non-typhoidal Salmonella infections in adult patients with sickle cell disease: a retrospective multicentre study. Infect Dis (Lond). 2018 Nov-Dec;50(11-12):822-30.[Abstract]
57. Feasey NA, Everett D, Faragher EB, et al. Modelling the contributions of malaria, HIV, malnutrition and rainfall to the decline in paediatric invasive non-typhoidal Salmonella disease in Malawi. PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003979.[Abstract][Full Text]
58. White AE, Tillman AR, Hedberg C, et al. Foodborne illness outbreaks reported to national surveillance, United States, 2009-2018. Emerg Infect Dis. 2022 Jun;28(6):1117-27.[Abstract][Full Text]
59. Talbot EA, Gagnon ER, Greenblatt J. Common ground for the control of multi-drug resistant Salmonella in ground beef. Clin Infect Dis. 2006 May 15;42(10):1455-62.[Abstract][Full Text]
60. Woodward DL, Khakhria R, Johnson WM. Human salmonellosis associated with exotic pets. J Clin Microbiol. 1997 Nov;35(11):2786-90.[Abstract][Full Text]
61. Waltenburg MA, Nichols M, Waechter H, et al. Notes from the field: recurrence of a multistate outbreak of Salmonella Typhimurium infections linked to contact with hedgehogs - United States and Canada, 2020. MMWR Morb Mortal Wkly Rep. 2021 Aug 13;70(32):1100-2.[Full Text]
62. National Association of State Public Health Veterinarians Animal Contact Compendium Committee, Daly RF, House J, et al. Compendium of measures to prevent disease associated with animals in public settings, 2017. J Am Vet Med Assoc. 2017 Dec 1;251(11):1268-92.[Full Text]
63. Finley R, Reid-Smith R, Weese S. Human health implications of Salmonella-contaminated natural pet treats and raw pet food. Clin Infect Dis. 2006 Mar 1;42(5):686-91.[Abstract][Full Text]
64. Centers for Disease Control and Prevention (CDC). Human salmonellosis associated with animal-derived pet treats - United States and Canada, 2005. MMWR Morb Mortal Wkly Rep. 2006 Jun 30;55(25):702-5.[Abstract][Full Text]
65. Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis. 2017 Nov 29;65(12):1963-73.[Abstract][Full Text]
66. Saphra I, Winter JW. Clinical manifestations of salmonellosis in man: an evaluation of 7779 infections identified at the New York Salmonella Center. N Engl J Med. 1957 Jun 13;256(24):1128-34.[Abstract]
67. Riddle MS, DuPont HL, Connor BA. ACG Clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016 May;111(5):602-22.[Abstract]
68. Buss SN, Leber A, Chapin K, et al. Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis. J Clin Microbiol. 2015 Mar;53(3):915-25.[Abstract][Full Text]
69. Pui CF, Wong WC, Chai LC, et al. Multiplex PCR for the concurrent detection and differentiation of Salmonella spp., Salmonella Typhi and Salmonella Typhimurium. Trop Med Health. 2011 Mar;39(1):9-15.[Abstract][Full Text]
70. Moon RC, Bleak TC, Rosenthal NA, et al. Relationship between diagnostic method and pathogen detection, healthcare resource use, and cost in U.S. adult outpatients treated for acute infectious gastroenteritis. J Clin Microbiol. 2023 Feb 22;61(2):e0162822.[Abstract][Full Text]
71. Shea S, Kubota KA, Maguire H, et al. Clinical microbiology laboratories' adoption of culture-independent diagnostic tests is a threat to foodborne-disease surveillance in the United States. J Clin Microbiol. 2017 Jan;55(1):10-9.[Abstract][Full Text]
72. Fang FC, Patel R. 2017 Infectious Diseases Society of America Infectious Diarrhea guidelines: a view from the clinical laboratory. Clin Infect Dis. 2017 Nov 29;65(12):1974-6.[Full Text]
73. Hashemi A, Baghbani-Arani F. The effective differentiation of Salmonella isolates using four PCR-based typing methods. J Appl Microbiol. 2015 Jun;118(6):1530-40.[Abstract][Full Text]
74. Pethplerdprao P, Supa-amornkul S, Panvisavas N, et al. Salmonella enterica multilocus sequence typing and its correlation with serotypes. Food Biotechnology. 2017;31(2):73-9.
75. Zhang S, Yin Y, Jones MB, et al. Salmonella serotype determination utilizing high-throughput genome sequencing data. J Clin Microbiol. 2015 May;53(5):1685-92.[Abstract][Full Text]
76. Mandomando I, Macete E, Sigaúque B, et al. Invasive non-typhoidal Salmonella in Mozambican children. Trop Med Int Health. 2009 Dec;14(12):1467-74.[Abstract][Full Text]
77. Preziosi MJ, Kandel SM, Guiney DG, et al. Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes of bacteremia or enteritis in HIV/AIDS patients in San Diego, California. J Clin Microbiol. 2012 Nov;50(11):3598-603.[Abstract][Full Text]
78. Cybulski RJ Jr, Bateman AC, Bourassa L, et al. Clinical impact of a multiplex gastrointestinal polymerase chain reaction panel in patients with acute gastroenteritis. Clin Infect Dis. 2018 Nov 13;67(11):1688-96.[Abstract][Full Text]
79. Ramos JM, Aguado JM, García-Corbeira P, et al. Clinical spectrum of urinary tract infections due on nontyphoidal Salmonella species. Clin Infect Dis. 1996 Aug;23(2):388-90.[Abstract][Full Text]
80. Paterson DL, Harrison MW, Robson JM. Clinical spectrum of urinary tract infections due to nontyphoidal Salmonella species. Clin Infect Dis. 1997 Sep;25(3):754.[Full Text]
81. American Medical Association; American Nurses Association-American Nurses Foundation; Centers for Disease Control and Prevention; Center for Food Safety and Applied Nutrition, Food and Drug Administration; Food Safety and Inspection Service, US Department of Agriculture. Diagnosis and management of foodborne illnesses: a primer for physicians and other health care professionals. MMWR Recomm Rep. 2004 Apr 16;53(RR-4):1-33.[Abstract][Full Text]
82. World Health Organization. Foodborne disease outbreaks: guidelines for investigation and control. Dec 2008 [internet publication].[Full Text]
83. Szajewska H, Dziechciarz P. Gastrointestinal infections in the pediatric population. Curr Opin Gastroenterol. 2010 Jan;26(1):36-44.[Abstract]
84. Florez ID, Sierra J, Pérez-Gaxiola G. Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children. Cochrane Database Syst Rev. 2023 May 17;5(5):CD013640.[Abstract][Full Text]
85. Onwuezobe IA, Oshun PO, Odigwe CC. Antimicrobials for treating symptomatic non-typhoidal Salmonella infection. Cochrane Database Syst Rev. 2012 Nov 14;11(11):CD001167.[Abstract][Full Text]
86. Khoshoo V, Raj P, Srivastava R, et al. Salmonella typhimurium-associated severe protracted diarrhea in infants and young children. J Pediatr Gastroenterol Nutr. 1990 Jan;10(1):33-6.[Abstract][Full Text]
87. Gendrel D, Raymond J, Legall MA, et al. Use of pefloxacin after failure of initial antibiotic treatment in children with severe salmonellosis. Eur J Clin Microbiol Infect Dis. 1993 Mar;12(3):209-11.[Abstract]
88. Mori N, Szvalb AD, Adachi JA, et al. Clinical presentation and outcomes of non-typhoidal Salmonella infections in patients with cancer. BMC Infect Dis. 2021 Sep 29;21(1):1021.[Abstract][Full Text]
89. Carlstedt G, Dahl P, Niklasson PM, et al. Norfloxacin treatment of salmonellosis does not shorten the carrier stage. Scand J Infect Dis. 1990 Jul 8;22(5):553-6.[Abstract]
90. Bassily S, Hyams KC, el-Masry NA, et al. Short-course norfloxacin and trimethoprim-sulfamethoxazole treatment of shigellosis and salmonellosis in Egypt. Am J Trop Med Hyg. 1994 Aug;51(2):219-23.[Abstract]
91. Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):132-52.[Abstract]
92. Gendrel D, Cohen R; European Society for Pediatric Infectious Diseases, European Society for Gastroenterology, Hepatology and Nutrition. Bacterial diarrheas and antibiotics: European recommendations. Arch Pediatr. 2008 Oct;15 Suppl 2:S93-6. [in French][Abstract]
93. Tarr PI, Freedman SB. Why antibiotics should not be used to treat Shiga toxin-producing Escherichia coli infections. Curr Opin Gastroenterol. 2022 Jan 1;38(1):30-8.[Abstract]
94. Gilbert DN, Chambers HF, Eliopoulos GM, et al. The Sanford guide to antimicrobial therapy, 47th ed. Sperryville, VA: Antimicrobial Therapy, Inc.; 2017.
95. Benenson S, Raveh D, Schlesinger Y, et al. The risk of vascular infection in adult patients with nontyphi Salmonella bacteremia. Am J Med. 2001 Jan;110(1):60-3.[Abstract]
96. Gordon MA, Banda HT, Gondwe M, et al. Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence. AIDS. 2002 Aug 16;16(12):1633-41.[Abstract]
97. Nakaya H, Yasuhara A, Yoshimura K, et al. Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica typhimurium with mutations in both gyrA and parC. Emerg Infect Dis. 2003 Feb;9(2):255-7.[Abstract]
98. Whichard JM, Gay K, Stevenson JE, et al. Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins. Emerg Infect Dis. 2007 Nov;13(11):1681-8.[Abstract]
99. Humphries RM, Fang FC, Aarestrup FM, et al. In vitro susceptibility testing of fluoroquinolone activity against Salmonella: recent changes to CLSI standards. Clin Infect Dis. 2012 Oct;55(8):1107-13.[Abstract][Full Text]
100. Al-Mashhadani M, Hewson R, Vivancos R, et al. Foreign travel and decreased ciprofloxacin susceptibility in Salmonella enterica infections. Emerg Infect Dis. 2011 Jan;17(1):123-5.[Abstract][Full Text]
101. Food and Drug Administration. FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together. Aug 2018 [internet publication].[Full Text]
102. European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. November 2018 [internet publication].[Full Text]
103. US Food & Drug Administraton. FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. 10 July 2018 [internet publication].[Full Text]
104. Food and Drug Administration (FDA). FDA Drug Safety Communication: FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. December 2018 [internet publication].[Full Text]
105. Sjölund-Karlsson M, Rickert R, Matar C, et al. Salmonella isolates with decreased susceptibility to extended-spectrum cephalosporins in the United States. Foodborne Pathog Dis. 2010 Dec;7(12):1503-9.[Abstract]
106. Wadula J, von Gottberg A, Kilner D, et al. Nosocomial outbreak of extended-spectrum beta-lactamase-producing Salmonella isangi in pediatric wards. Pediatr Infect Dis J. 2006 Sep;25(9):843-4.[Abstract]
107. Usha G, Chunderika M, Prashini M, et al. Characterization of extended-spectrum beta-lactamases in Salmonella spp. at a tertiary hospital in Durban, South Africa. Diagn Microbiol Infect Dis. 2008 Sep;62(1):86-91.[Abstract]
108. Lunguya O, Lejon V, Phoba MF, et al. Antimicrobial resistance in invasive non-typhoid Salmonella from the Democratic Republic of the Congo: emergence of decreased fluoroquinolone susceptibility and extended-spectrum beta lactamases. PLoS Negl Trop Dis. 2013 Mar;7(3):e2103.[Abstract][Full Text]
109. White NJ, Dung NM, Vinh H, et al. Fluoroquinolone antibiotics in children with multidrug resistant typhoid. Lancet. 1996 Aug 24;348(9026):547.[Abstract]
110. Adefurin A, Sammons H, Jacqz-Aigrain, et al. Ciprofloxacin safety in paediatrics: a systematic review. Arch Dis Child. 2011 Sep;96(9):874-80.[Abstract][Full Text]
111. Tang HJ, Ko WC, Chen CC, et al. In vitro and in vivo intracellular killing effects of tigecycline against clinical nontyphoid Salmonella isolates using ceftriaxone as a comparator. Antimicrob Agents Chemother. 2011 Jun;55(6):2755-9.[Abstract][Full Text]
112. Tang HJ, Chen CC, Zhang CC, et al. Use of Carbapenems against clinical, nontyphoid Salmonella isolates: results from in vitro and in vivo animal studies. Antimicrob Agents Chemother. 2012 Jun;56(6):2916-22.[Abstract][Full Text]
113. Tang HJ, Chen CC, Ko WC. Tigecycline therapy for bacteremia and aortitis caused by Salmonella enterica serotype choleraesuis: a case report. J Microbiol Immunol Infect. 2016 Feb;49(1):131-3.[Abstract][Full Text]
114. Kleine CE, Schlabe S, Hischebeth GTR, et al. Successful therapy of a multidrug-resistant extended-spectrum beta-lactamase-producing and fluoroquinolone-resistant Salmonella enterica subspecies enterica serovar typhi infection using combination therapy of meropenem and fosfomycin. Clin Infect Dis. 2017 Oct 30;65(10):1754-6.[Abstract][Full Text]
115. Blumentrath CG, Müller G, Teichmann D, et al. Relapse of typhoid fever following delayed response to meropenem: a case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever. Ger Med Sci. 2019 Jan 7;17:Doc01.[Abstract][Full Text]
116. Freerksen E, Rosenfield M, Freerksen R, et al. Treatment of chronic Salmonella carriers. Chemotherapy. 1977;23(3):192-210.[Abstract]
117. Ferreccio C, Morris JG Jr, Valdivieso C, et al. Efficacy of ciprofloxacin in the treatment of chronic typhoid carriers. J Infect Dis. 1988 Jun;157(6):1235-9.[Abstract]
118. DuPont HL. Quinolones in Salmonella typhi infection. Drugs. 1993;45 Suppl 3:119-24.[Abstract]
119. Diridl G, Pichler H, Wolf D. Treatment of chronic salmonella carriers with ciprofloxacin. Eur J Clin Microbiol. 1986 Apr;5(2):260-1.[Abstract]
120. Clementi KJ. Trimethoprim-sulfamethoxazole in the treatment of carriers of Salmonella. J Infect Dis. 1973 Nov;128:Suppl:738-42.[Abstract]
121. Rodriguez-Noriega E, Andrade-Villanueva J, Amaya-Tapia G. Quinolones in the treatment of Salmonella carriers. Rev Infect Dis. Jul-Aug 1989;11 Suppl 5:S1179-87.[Abstract]
122. Dinbar A, Altmann G, Tulcinsky DB. The treatment of chronic biliary salmonella carriers. Am J Med. 1969 Aug;47(2):236-42.[Abstract]
123. Cummings PL, Sorvillo F, Kuo T. Salmonellosis-related mortality in the United States, 1990-2006. Foodborne Pathog Dis. 2010 Nov;7(11):1393-9.[Abstract]
124. Marchello CS, Birkhold M, Crump JA, et al. Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis. Lancet Infect Dis. 2022 May;22(5):692-705.[Abstract][Full Text]
125. Laupland KB, Schønheyder HC, Kennedy KJ, et al. Salmonella enterica bacteraemia: a multi-national population-based cohort study. BMC Infect Dis. 2010 Apr 14;10:95.[Abstract][Full Text]
126. Feasey NA, Archer BN, Heyderman RS, et al. Typhoid fever and invasive nontyphoid salmonellosis, Malawi and South Africa. Emerg Infect Dis. 2010 Sep;16(9):1448-51.[Abstract][Full Text]
127. Soravia-Dunand VA, Loo VG, Salit IE. Aortitis due to Salmonella: report of 10 cases and comprehensive review of the literature. Clin Infect Dis. 1999 Oct;29(4):862-8.[Abstract][Full Text]
128. Kaneko K, Nonomura Y, Watanabe K, et al. Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritis. J Infect Chemother. 2009 Oct;15(5):312-5.[Abstract]
129. Chen PL, Lee CC, Li CY, et al. A simple scoring algorithm predicting vascular infections in adults with nontyphoid Salmonella bacteremia. Clin Infect Dis. 2012 Jul;55(2):194-200.[Abstract]
130. Lee AT, Hall RG, Pile KD. Reactive joint symptoms following an outbreak of Salmonella typhimurium phage type 135a. J Rheumatol. 2005 Mar;32(3):524-7.[Abstract]
131. Buchwald DS, Blaser MJ. A review of human salmonellosis: II. duration of excretion following infection with nontyphi Salmonella. Rev Infect Dis. May-Jun 1984;6(3):345-56.[Abstract]
132. Lee MB, Greig JD. A review of nosocomial Salmonella outbreaks: infection control interventions found effective. Public Health. 2013 Mar;127(3):199-206.[Abstract]
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