Highlights & Basics
- Brain abscess is a potentially life-threatening condition, with clinical and radiologic presentation similar to central nervous system tumor. Early recognition is required for optimal outcome.
- Lesions may be single or multifocal. Etiologic agents may be bacterial, fungal, and parasitic.
- Treatments include appropriate antimicrobial agents, support in an intensive care unit, and possible surgical evacuation. Surgery involves either image-guided aspiration or craniotomy with resection of the abscess cavity.
- Patients must be followed up with serial imaging until their lesions have completely resolved.
- Prognosis is most closely related to the patient's neurologic status at presentation.
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Citations
Hall WA, Truwit CL. The surgical management of infections involving the cerebrum. Neurosurgery. 2008 Feb;62(2 suppl):519-30.[Abstract]
Brouwer MC, Coutinho JM, van de Beek D. Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis. Neurology. 2014 Mar 4;82(9):806-13.[Abstract]
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Expert Panel on Neurologic Imaging; Whitehead MT, Cardenas AM, et al. ACR Appropriateness Criteria® headache. J Am Coll Radiol. 2019 Nov;16(11s):S364-77.[Abstract][Full Text]
American College of Radiology. ACR-ASNR-SPR practice parameter for the performance and interpretation of magnetic resonance spectroscopy of the central nervous system. 2019 [internet publication].[Full Text]
Infection in Neurosurgery Working Party of the British Society for Antimicrobial Chemotherapy. The rational use of antibiotics in the treatment of brain abscess. Br J Neurosurg. 2000 Dec;14(6):525-30.[Abstract]
Mampalam TJ, Rosenblum ML. Trends in the management of bacterial brain abscesses: a review of 102 cases over 17 years. Neurosurgery. 1988 Oct;23(4):451-8.[Abstract]
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46. Neuwelt EA, Lawrence MS, Blank NK. Effect of gentamicin and dexamethasone on the natural history of the rat Escherichia coli brain abscess model with histopathological correlation. Neurosurgery. 1984 Oct;15(4):475-83.[Abstract]
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54. Mampalam TJ, Rosenblum ML. Trends in the management of bacterial brain abscesses: a review of 102 cases over 17 years. Neurosurgery. 1988 Oct;23(4):451-8.[Abstract]
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