Wilms tumor - Symptoms, Causes, Images, and Treatment Options

Diseases

Highlights & Basics

Key Highlights

Wilms tumor is the most common renal malignancy in children.
Usually presents as a unilateral, painless, abdominal/flank mass; less commonly presents bilaterally.
Metastatic disease occurs in <10% of patients and needs to be carefully excluded using ultrasound and computed tomography/magnetic resonance imaging.
Long-term survival approaches 90% in localized disease.
Treatment is with nephrectomy, chemotherapy, and radiation therapy.

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Definition

Epidemiology

Etiology

Pathophysiology

Citations

Key Articles

Spreafico F, Fernandez CV, Brok J, et al. Wilms tumour. Nat Rev Dis Primers. 2021 Oct 14;7(1):75.[Abstract][Full Text]
Lopyan NM, Ehrlich PF. Surgical management of Wilms tumor (nephroblastoma) and renal cell carcinoma in children and young adults. Surg Oncol Clin N Am. 2021 Apr;30(2):305-23.[Abstract]
Vujanić GM, Parsons LN, D'Hooghe E, et al. Pathology of Wilms' tumour in International Society of Paediatric Oncology (SIOP) and Children's Oncology Group (COG) renal tumour studies: similarities and differences. Histopathology. 2022 Jun;80(7):1026-37.[Abstract]
van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, et al. Position paper: rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol. 2017 Dec;14(12):743-52.[Abstract][Full Text]
Dome JS, Mullen EA, Dix DB, et al. Impact of the first generation of Children's Oncology Group clinical trials on clinical practice for Wilms tumor. J Natl Compr Canc Netw. 2021 Aug 1;19(8):978-85.[Abstract][Full Text]

Referenced Articles

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