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Diseases

Evaluation of tremor

OVERVIEW

  • Summary
  • Urgent Considerations
  • Etiology

DIAGNOSIS

  • Differential Diagnosis
  • Diagnostic Approach

IMAGES

  • Library

REFERENCES

  • Citations
  • Credits

Summary

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Tremor is defined as an involuntary oscillatory and rhythmic movement of a body part.[1]​ It commonly affects the upper extremities but can also affect the head, chin, voice, or legs. Tremor, if severe, may impair activities of daily living or occupation, and may lead to embarrassment and social withdrawal.
The rhythmicity of tremor differentiates it from other involuntary movements such as myoclonus, clonus, chorea, dystonia, and tics, although patients with these other conditions may complain of "shaking" or "tremulousness". For appropriate diagnosis and treatment, it is critical to determine the positional properties that make the tremor most noticeable. Most tremors can be classified as "rest" or "action".
  • Rest tremors occur when the body region is relaxed (i.e., not actively moving, contracting, sustaining a position, or opposing gravity). Examples include tremor in a hand relaxed by the side when walking or resting in a lap when sitting.

  • Action tremors occur during voluntary muscle contraction. They are further divided into postural, kinetic, isometric, or task-specific subtypes.
    • Postural tremors occur during maintenance of a posture, usually against gravity (e.g., holding up a newspaper).

    • Kinetic tremors occur during active movement. A subtype of kinetic tremor, intention tremor, is seen with a goal-directed movement (e.g., finger-to-nose testing). Action tremors are often both postural and kinetic.

    • Isometric and task-specific subtypes are uncommon. Isometric tremors occur during muscle contractions without movement (e.g., fist-clenching or standing). Task-specific tremors occur with a specific activity (e.g., writing or playing an instrument).

content by BMJ Group
Last updated

Citations

    Key Articles

    • Bhatia KP, Bain P, Bajaj N, et al. Consensus statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018 Jan;33(1):75-87.[Abstract][Full Text]

    • Shanker V. Essential tremor: diagnosis and management. BMJ. 2019 Aug 5;366:l4485.[Abstract][Full Text]

    • American College of Radiology. ACR appropriateness criteria: movement disorders and neurodegenerative diseases. 2019 [internet publication].[Full Text]

    Referenced Articles

    • 1. Bhatia KP, Bain P, Bajaj N, et al. Consensus statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018 Jan;33(1):75-87.[Abstract][Full Text]

    • 2. Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181-184.[Abstract][Full Text]

    • 3. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863-1872.[Abstract]

    • 4. Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008 Aug 26;71(9):670-6.[Abstract][Full Text]

    • 5. Litvan I, Campbell G, Mangone CA, et al. Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study. Brain. 1997 Jan;120 (Pt 1):65-74.[Abstract][Full Text]

    • 6. Lenka A, Jankovic J. Tremor syndromes: an updated review. Front Neurol. 2021 Jul 26;12:684835.[Abstract][Full Text]

    • 7. Cohen O, Pullman S, Jurewicz E, et al. Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics. Arch Neurol. 2003 Mar;60(3):405-10.[Abstract]

    • 8. Louis ED. Essential tremor. Lancet Neurol. 2005 Feb;4(2):100-10.[Abstract]

    • 9. Okelberry T, Lyons KE, Pahwa R. Updates in essential tremor. Parkinsonism Relat Disord. 2024 May;122:106086.[Abstract][Full Text]

    • 10. Shanker V. Essential tremor: diagnosis and management. BMJ. 2019 Aug 5;366:l4485.[Abstract][Full Text]

    • 11. Zesiewicz TA, Elble RJ, Louis ED, et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology. Neurology. 2011 Nov 8;77(19):1752-5.[Abstract][Full Text]

    • 12. Mostile G, Jankovic J. Alcohol in essential tremor and other movement disorders. Mov Disord. 2010 Oct 30;25(14):2274-84.[Abstract]

    • 13. Cabal-Herrera AM, Tassanakijpanich N, Salcedo-Arellano MJ, et al. Fragile X-associated tremor/ataxia syndrome (FXTAS): pathophysiology and clinical implications. Int J Mol Sci. 2020 Jun;21(12):4391.[Abstract][Full Text]

    • 14. Hagerman RJ, Hagerman P. Fragile X-associated tremor/ataxia syndrome - features, mechanisms and management. Nat Rev Neurol. 2016 Jul;12(7):403-12.[Abstract]

    • 15. Wu J, Tang H, Chen S, et al. Mechanisms and pharmacotherapy for ethanol-responsive movement disorders. Front Neurol. 2020 Aug 25;11:892.[Abstract][Full Text]

    • 16. Shaikh AG, Fasano A, Pandey S, et al. Challenges in describing tremor and dystonia. Neurology. 2025 Jan 28;104(2):e210209.[Abstract]

    • 17. Schilsky ML, Roberts EA, Bronstein JM, et al. A multidisciplinary approach to the diagnosis and management of Wilson disease: 2022 practice guidance on Wilson disease from the American Association for the Study of Liver Diseases. Hepatology. 2025 Sep 1;82(3):E41-90.[Full Text]

    • 18. American College of Radiology. ACR appropriateness criteria: movement disorders and neurodegenerative diseases. 2019 [internet publication].[Full Text]

    • 19. Yomtoob J, Koloms K, Bega D. DAT-SPECT imaging in cases of drug-induced parkinsonism in a specialty movement disorders practice. Parkinsonism Relat Disord. 2018 Aug;53:37-41.[Abstract]

    • 20. Yekhlef F, Ballan G, Macia F, et al. Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD. J Neural Transm. 2003;110:151-169.[Abstract]

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