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fluorouracil
generic
Black Box Warnings .
Serious Adverse Reactions Or Death In Patients With Complete DPD Deficiency
test for genetic variants of dihydropyrimidine dehydrogenase (DPYD) prior to initiating unless immediate treatment necessary; avoid use in patients with certain homozygous or compound heterozygous DPYD variants resulting in complete DPD deficiency
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments
colorectal CA
- [infusion regimen]
- Dose: 400 mg/m^2/dose IV x1 on day 1, then 1200-1500 mg/m^2/24h IV continuous infusion on days 1, 2 of 14-day cycle; Info: use with (levo)leucovorin or part of multi-drug chemo regimen
- [bolus regimen]
- Dose: 500 mg/m^2/dose IV x1 on days 1, 8, 15, 22, 29, 36 of 56-day cycle; Info: use with (levo)leucovorin
breast CA
- [500 mg/m^2/dose IV x1 on days 1, 8 of 28-day cycle]
- Alt: 600 mg/m^2/dose IV x1 on days 1, 8 of 28-day cycle; Info: give x6 cycles; part of multi-drug chemo regimen
gastric CA
- [200-1000 mg/m^2/24h IV continuous infusion on specific day(s) of cycle per regimen]
- Info: part of multi-drug chemo regimen
pancreatic CA
- [400 mg/m^2/dose IV x1 on day 1, then 1200 mg/m^2/24h IV continuous infusion on days 1, 2 of 14-day cycle]
- Info: use with (levo)leucovorin or part of multi-drug chemo regimen
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: decr. usual dose by up to 50%, on dialysis days administer after dialysis; no supplement; PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.