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Skytrofa (lonapegsomatropin-tcgd)
lonapegsomatropin
Adult Dosing .
Dosage forms: INJ (cartridge): 0.7 mg per injection, 1.4 mg per injection, 1.8 mg per injection, 2.1 mg per injection, 2.5 mg per injection, 3 mg per injection, 3.6 mg per injection, 4.3 mg per injection, 5.2 mg per injection, 6.3 mg per injection, 7.6 mg per injection, 9.1 mg per injection, 11 mg per injection, 13.3 mg per injection
Special Note
- [drug name clarification]
- Info: nonproprietary name = lonapegsomatropin-tcgd
growth hormone deficiency
- [<30 yo or w/ concurrent PO estrogen use]
- Dose: individualize dose SC qwk; Start: 2.1 mg SC qwk, may incr. dose qmo; Max: 6.3 mg/wk; Info: adjust dose based on IGF-1 levels and sx; cartridges for use w/ Skytrofa auto-injector only
- [30-60 yo w/o concurrent PO estrogen use]
- Dose: individualize dose SC qwk; Start: 1.4 mg SC qwk, may incr. dose qmo; Max: 6.3 mg/wk; Info: adjust dose based on IGF-1 levels and sx; cartridges for use w/ Skytrofa auto-injector only
- [>60 yo w/o concurrent PO estrogen use]
- Dose: individualize dose SC qwk; Start: 0.7 mg SC qwk, may incr. dose qmo; Max: 6.3 mg/wk; Info: adjust dose based on IGF-1 levels and sx; cartridges for use w/ Skytrofa auto-injector only
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (cartridge): 3 mg per injection, 3.6 mg per injection, 4.3 mg per injection, 5.2 mg per injection, 6.3 mg per injection, 7.6 mg per injection, 9.1 mg per injection, 11 mg per injection, 13.3 mg per injection
Special Note
- [drug name clarification]
- Info: nonproprietary name = lonapegsomatropin-tcgd
growth hormone deficiency
- [1 yo and older, >11.5 kg]
- Dose: 0.24 mg/kg/dose SC qwk; Info: round dose to nearest cartridge size; adjust dose based on tx response; cartridges for use w/ Skytrofa auto-injector only; D/C when pt reaches satisfactory ht, epiphyses close, or no response
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]