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Norvir
ritonavir
Black Box Warnings .
Drug Interactions
potential serious and/or life-threatening adverse effects in combo w/ certain sedative hypnotics, antiarrhythmics, or ergot alkaloids due to inhibited drug metabolism by ritonavir; review medications prior to prescribing ritonavir or when prescribing other medications to pts already taking ritonavir
Adult Dosing .
Dosage forms: TAB: 100 mg; PWDR: 100 mg per pkt
HIV infection, protease inhibitor boosting
- [100-400 mg/day PO divided qd-bid]
- Info: dosing varies based on concomitant PI; see other PI monographs for specific ritonavir dosing; do not cut/crush/chew tab; give w/ food
HIV post-exposure prophylaxis (off-label)
- [protease inhibitor boosting]
- Dose: 100 mg PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; do not cut/crush/chew tab; give w/ food
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
Peds Dosing .
- Dosage forms: TAB: 100 mg; PWDR: 100 mg per pkt
HIV infection, protease inhibitor boosting
- [>1 mo]
- Info: dosing varies based on concomitant PI; see other PI monographs for specific ritonavir dosing; do not cut/crush/chew tab; give w/ food
HIV post-exposure prophylaxis, nonoccupational (off-label)
- [protease inhibitor boosting, >3 yo]
- Info: dosing varies based on concomitant PI; see other PI monographs for specific ritonavir dosing; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; do not cut/crush/chew tab; give w/ food
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined