Cortrophin Gel

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe, SC): 40 units per 0.5 mL, 80 units per mL; INJ (vial, SC/IM): 80 units per mL

corticotropin-responsive conditions

[40-80 units SC/IM q24-72h]

Info: consider test dose before tx start; individualize dose, frequency based on condition, dz severity, initial tx response; use lowest effective dose; taper dose gradually to D/C

multiple sclerosis, acute exacerbation

[80-120 units SC/IM qd x2-3wk]

Info: consider test dose before tx start; individualize dose based on dz severity, initial tx response; use lowest effective dose; taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (pre-filled syringe, SC): 40 units per 0.5 mL, 80 units per mL; INJ (vial, SC/IM): 80 units per mL

corticotropin-responsive conditions

[40-80 units SC/IM q24-72h]

Info: consider test dose before tx start; individualize dose, frequency based on condition, dz severity, initial tx response; use lowest effective dose; taper dose gradually to D/C

infantile spasms (off-label)

[high-dose tx, <2 yo]

Dose: 150 units/m^2/day IM divided bid x2wk; Info: taper dose gradually over 2wk to D/C; may consider taper of 30 units/m^2/dose IM qam x3 days, then 15 units/m^2/dose IM qam x3 days, then 10 units/m^2/dose IM qam x3 days, then 10 units/m^2/dose IM every other am x6 days

[low-dose tx, <2 yo]

Dose: 20-30 units/m^2/dose IM qd; Info: taper dose gradually over 2wk to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]