Ztalmy

Adult Dosing .

Dosage forms:  SUSP: 50 mg per mL

seizures, CDKL5 deficiency disorder-associated

[600 mg PO tid]

Start: 150 mg PO tid, then may incr. by 150 mg/dose no more frequently than q7 days; Max: 1800 mg/day; Info: give w/ food; taper dose gradually to D/C

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: start 50 mg tid, then may incr. by 50 mg/dose no more frequently than q7 days, max 600 mg/day

Peds Dosing .

Dosage forms:  SUSP: 50 mg per mL

seizures, CDKL5 deficiency disorder-associated

[2 yo and older, <28 kg]

Dose: 21 mg/kg/dose PO tid; Start: 6 mg/kg/dose PO tid, then may incr. by 5 mg/kg/dose no more frequently than q7 days; Max: 63 mg/kg/day; Info: give w/ food; taper dose gradually to D/C

[2 yo and older, >28 kg]

Dose: 600 mg PO tid; Start: 150 mg PO tid, then may incr. by 150 mg/dose no more frequently than q7 days; Max: 1800 mg/day; Info: give w/ food; taper dose gradually to D/C

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[<28 kg]

Child-Pugh Class C: start 6 mg/kg/day divided tid, then may incr. by 5 mg/kg/day divided tid no more frequently than q7 days, max 21 mg/kg/day

[>28 kg]

Child-Pugh Class C: start 50 mg tid, then may incr. by 50 mg/dose no more frequently than q7 days, max 600 mg/day