Ztalmy

Adult Dosing .

Dosage forms:  SUSPENSION: 50 mg per mL

seizures, CDKL5 deficiency disorder-associated

[600 mg PO tid]

Start: 50 mg PO tid x7 days, then may incr. to 100 mg PO tid x7 days, then may incr. to 200 mg PO tid x7 days, then may incr. to 400 mg PO tid x7 days; Max: 1800 mg/day; Info: give with food; taper dose gradually to D/C

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: start 17 mg tid x7 days, then may incr. to 33 mg tid x7 days, then may incr. to 67 mg tid x7 days, then may incr. to 133 mg tid x7 days, then may incr. to 200 mg tid; max 600 mg/day

Peds Dosing .

Dosage forms:  SUSPENSION: 50 mg per mL

seizures, CDKL5 deficiency disorder-associated

[2 yo and older, <28 kg]

Dose: 21 mg/kg/dose PO tid; Start: 2 mg/kg/dose PO tid x7 days, then may incr. to 4 mg/kg/dose PO tid x7 days, then may incr. to 8 mg/kg/dose PO tid x7 days, then may incr. to 14 mg/kg/dose PO tid x7 days; Max: 63 mg/kg/day; Info: give with food; taper dose gradually to D/C

[2 yo and older, >28 kg]

Dose: 600 mg PO tid; Start: 50 mg PO tid x7 days, then may incr. to 100 mg PO tid x7 days, then may incr. to 200 mg PO tid x7 days, then may incr. to 400 mg PO tid x7 days; Max: 1800 mg/day; Info: give with food; taper dose gradually to D/C

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[<28 kg]

Child-Pugh Class C: start 0.66 mg/kg/dose tid x7 days, then may incr. to 1.33 mg/kg/dose tid x7 days, then may incr. to 2.66 mg/kg/dose tid x7 days, then may incr. to 4.66 mg/kg/dose tid x7 days, then may incr. to 7 mg/kg/dose tid, max 21 mg/kg/day

[>28 kg]

Child-Pugh Class C: start 17 mg tid x7 days, then may incr. to 33 mg tid x7 days, then may incr. to 67 mg tid x7 days, then may incr. to 133 mg tid x7 days, then may incr. to 200 mg tid; max 600 mg/day