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mitomycin
generic
Black Box Warnings .
Appropriate Use
admin. only under supervision of physician experienced in cancer chemotherapy in adequate medical facility to manage complications
Myelosuppression
most common and severe adverse effect; primarily thrombocytopenia and neutropenia; may lead to overwhelming infections in already compromised pt
Hemolytic Uremic Syndrome
incl. microangiopathic hemolytic anemia, thrombocytopenia, and irreversible renal failure; can occur at any time during monotherapy or in combo w/ other cytotoxic drugs, most cases at >60 mg mitomycin; blood product transfusion may exacerbate sx
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
stomach CA, refractory
- [20 mg/m^2/dose IV x1 on day 1 of 42- or 56-day cycle]
- Info: part of multi-drug chemo regimen
pancreatic CA, refractory
- [20 mg/m^2/dose IV x1 on day 1 of 42- or 56-day cycle]
- Info: part of multi-drug chemo regimen
renal dosing
- [see below]
- Cr >1.7: avoid use
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.