Spevigo (spesolimab-sbzo)

Adult Dosing .

Dosage forms:  INJ (SC pre-filled syringe): 150 mg per mL, 300 mg per 2 mL; INJ (IV vial): various

Special Note

[drug name clarification]

Info: nonproprietary name = spesolimab-sbzo

generalized pustular psoriasis, flare tx

[900 mg IV x1]

Info: may repeat dose x1 after 1wk if flare symptoms persist

generalized pustular psoriasis, maintenance tx

[spesolimab-naive patients]

Dose: 300 mg SC q4wk; Start: 600 mg SC x1, then 4wk later, 300 mg SC q4wk; Info: if maintenance tx interrupted for IV flare tx, restart 300 mg SC q4wk maintenance tx 4wk after last IV dose

[conversion from spesolimab IV flare tx]

Dose: 300 mg SC q4wk; Start: 4wk after last IV dose; Info: if maintenance tx interrupted for IV flare tx, restart 300 mg SC q4wk maintenance tx 4wk after last IV dose

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (SC pre-filled syringe): 150 mg per mL, 300 mg per 2 mL; INJ (IV vial): various

Special Note

[drug name clarification]

Info: nonproprietary name = spesolimab-sbzo

generalized pustular psoriasis, flare tx

[12 yo and older, >40 kg]

Dose: 900 mg IV x1; Info: may repeat dose x1 after 1wk if flare symptoms persist

generalized pustular psoriasis, maintenance tx

[spesolimab-naive patients, 12 yo and older, >40 kg]

Dose: 300 mg SC q4wk; Start: 600 mg SC x1, then 4wk later, 300 mg SC q4wk; Info: if maintenance tx interrupted for IV flare tx, restart 300 mg SC q4wk maintenance tx 4wk after last IV dose

[conversion from spesolimab IV flare tx, 12 yo and older, >40 kg]

Dose: 300 mg SC q4wk; Start: 4wk after last IV dose; Info: if maintenance tx interrupted for IV flare tx, restart 300 mg SC q4wk maintenance tx 4wk after last IV dose

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]