Krazati

Adult Dosing .

Dosage forms:  TAB: 200 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

KRAS G12C-mutated non-small cell lung CA, locally advanced or metastatic

[600 mg PO bid]

Info: for patients who have received at least 1 prior tx; do not cut/crush/chew tab

KRAS G12C-mutated colorectal CA, locally advanced or metastatic

[600 mg PO bid]

Info: for patients who have received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based tx; use with cetuximab; may continue as monotherapy if cetuximab permanently D/C'd; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.