Altuviiio (antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl)

Adult Dosing .

Dosage forms:  INJ

Special Note

[drug name clarification]

Info: nonproprietary name = antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approximately 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor-moderate]

Dose: 50 unit/kg/dose IV x1; Info: consider 30 unit/kg/dose if routine prophylaxis given within prior 2-3 days; may give additional 30-50 unit/kg/dose IV q2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, major]

Dose: 50 unit/kg/dose IV x1; Info: may give additional 30-50 unit/kg/dose IV q2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, minor surgery]

Dose: 50 unit/kg/dose IV x1 preop; Info: may give additional 30-50 unit/kg/dose IV x1 after 2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, major surgery]

Dose: 50 unit/kg/dose IV x1 preop; Info: may give additional 30-50 unit/kg/dose IV q2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[routine bleeding prophylaxis]

Dose: 50 units/kg/dose IV qwk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[drug name clarification]

Info: nonproprietary name = antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approximately 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor-moderate]

Dose: 50 unit/kg/dose IV x1; Info: consider 30 unit/kg/dose if routine prophylaxis given within prior 2-3 days; may give additional 30-50 unit/kg/dose IV q2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, major]

Dose: 50 unit/kg/dose IV x1; Info: may give additional 30-50 unit/kg/dose IV q2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, minor surgery]

Dose: 50 unit/kg/dose IV x1 preop; Info: may give additional 30-50 unit/kg/dose IV x1 after 2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, major surgery]

Dose: 50 unit/kg/dose IV x1 preop; Info: may give additional 30-50 unit/kg/dose IV q2-3 days; may alternatively estimate dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[routine bleeding prophylaxis]

Dose: 50 units/kg/dose IV qwk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]