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Exxua
gepirone
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds pts
Adult Dosing .
Dosage forms: ER TAB: 18.2 mg, 36.3 mg, 54.5 mg, 72.6 mg
major depressive disorder
- [18.2-72.6 mg PO qd]
- Start: 18.2 mg PO qd x3 days, then may incr. to 36.3 mg PO qd x4 days, then may incr. to 54.5 mg PO qd x1wk, then may incr. to 72.6 mg PO qd; Max: 72.6 mg/day; Info: start 18.2 mg PO qd x7 days, max 36.3 mg/day in elderly pts; give w/ food; do not cut/crush/chew tab; do not incr. dose if QTc >450 msec
renal dosing
- [adjust dose amount]
- CrCl <50: start 18.2 mg qd x7 days, max 36.3 mg/day
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B: start 18.2 mg qd x7 days, max 36.3 mg/day; Child-Pugh Class C: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.