Xacduro

Adult Dosing .

Dosage forms:  convenience pack

Special Note

[convenience pack components]

Info: pack contains sulbactam 1 g vial x1 and durlobactam 0.5 g vial x2

[strength clarification]

Info: 1 dose = sulbactam 1 g + durlobactam 1 g

pneumonia, hospital-acquired or ventilator-assoc.

[1 dose IV q6h x7 days]

Info: due to Acinetobacter baumannii-calcoaceticus complex; may extend duration based on clinical response; refer to IDSA guidelines; give 1 dose IV q4h if CrCl >130

renal dosing

[see below]

CrCl >130: 1 dose q4h; CrCl 45-129: 1 dose q6h; CrCl 30-44: 1 dose q8h; CrCl 15-29: 1 dose q12h; CrCl <15: 1 dose q24h, start 1 dose q12h x3 doses

HD: 1 dose q24h, start 1 dose q12h x3 doses, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.