Motpoly XR

Adult Dosing .

Dosage forms:  ER CAP: 100 mg, 150 mg, 200 mg

partial seizures

[monotherapy]

Dose: 300-400 mg PO qd; Start: 200 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Max: 400 mg/day; Info: for conversion from AED monotherapy, give ER lacosamide maint. dose for >4 days before gradual withdrawal of previous AED over >6wk; do not open cap; titrate w/ caution in elderly pts; taper dose over >1wk to D/C

[adjunct tx]

Dose: 200-400 mg PO qd; Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Max: 400 mg/day; Info: do not open cap; titrate w/ caution in elderly pts; taper dose over >1wk to D/C

primary generalized tonic clonic seizures, adjunct tx

[200-400 mg PO qd]

Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Max: 400 mg/day; Info: do not open cap; titrate w/ caution in elderly pts; taper dose over >1wk to D/C

renal dosing

[adjust dose amount]

CrCl <30: max 300 mg/day

HD: max 300 mg/day; give up to 50% usual dose as supplement after dialysis; PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: max 300 mg/day; severe impairment: avoid use

Peds Dosing .

Dosage forms:  ER CAP: 100 mg, 150 mg, 200 mg

partial seizures, monotherapy

[<17 yo, >50 kg]

Dose: 300-400 mg PO qd; Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Info: for conversion from AED monotherapy, give ER lacosamide maint. dose for >4 days before gradual withdrawal of previous AED over >6wk; do not open cap; taper dose over >1wk to D/C

[17 yo and older]

Dose: 300-400 mg PO qd; Start: 200 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Max: 400 mg/day; Info: for conversion from AED monotherapy, give ER lacosamide maint. dose for >4 days before gradual withdrawal of previous AED over >6wk; do not open cap; taper dose over >1wk to D/C

partial seizures, adjunct tx

[<17 yo, >50 kg]

Dose: 200-400 mg PO qd; Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Info: do not open cap; taper dose over >1wk to D/C

[17 yo and older]

Dose: 200-400 mg PO qd; Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Max: 400 mg/day; Info: do not open cap; taper dose over >1wk to D/C

primary generalized tonic clonic seizures, adjunct tx

[<17 yo, >50 kg]

Dose: 200-400 mg PO qd; Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Info: do not open cap; taper dose over >1wk to D/C

[17 yo and older]

Dose: 200-400 mg PO qd; Start: 100 mg PO qd, incr. by 100 mg/day no more frequently than qwk; Max: 400 mg/day; Info: do not open cap; taper dose over >1wk to D/C

renal dosing

[adjust dose amount]

CrCl <30: max 300 mg/day

HD: max 300 mg/day; give up to 50% usual dose as supplement after dialysis; PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: max 300 mg/day; severe impairment: avoid use