Ojemda

Adult Dosing .

Dosage forms:  TAB: 100 mg; SUSP: 25 mg per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

pediatric low-grade glioma, relapsed or refractory

[tab form, BSA 0.9-1.12 m^2]

Dose: 400 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation; do not cut/crush/chew tab

[tab form, BSA 1.13-1.39 m^2]

Dose: 500 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation; do not cut/crush/chew tab

[tab form, BSA >1.4 m^2]

Dose: 600 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation; do not cut/crush/chew tab

[suspension form, BSA 0.9-1.05 m^2]

Dose: 375 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, BSA 1.06-1.25 m^2]

Dose: 450 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, BSA 1.26-1.39 m^2]

Dose: 525 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, BSA >1.4 m^2]

Dose: 600 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined

Peds Dosing .

Dosage forms:  TAB: 100 mg; SUSP: 25 mg per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

pediatric low-grade glioma, relapsed or refractory

[tab form, 6 mo and older, BSA 0.9-1.12 m^2]

Dose: 400 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation; do not cut/crush/chew tab

[tab form, 6 mo and older, BSA 1.13-1.39 m^2]

Dose: 500 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation; do not cut/crush/chew tab

[tab form, 6 mo and older, BSA >1.4 m^2]

Dose: 600 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation; do not cut/crush/chew tab

[suspension form, 6 mo and older, BSA 0.3-0.35 m^2]

Dose: 125 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.36-0.42 m^2]

Dose: 150 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.43-0.48 m^2]

Dose: 175 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.49-0.54 m^2]

Dose: 200 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.55-0.63 m^2]

Dose: 225 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.64-0.77 m^2]

Dose: 275 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.78-0.83 m^2]

Dose: 300 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.84-0.89 m^2]

Dose: 350 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 0.9-1.05 m^2]

Dose: 375 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 1.06-1.25 m^2]

Dose: 450 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA 1.26-1.39 m^2]

Dose: 525 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

[suspension form, 6 mo and older, BSA >1.4 m^2]

Dose: 600 mg PO qwk; Info: for pts w/ BRAF fusion or rearrangement, or BRAF V600 mutation

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined