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Imdelltra (tarlatamab-dlle)
tarlatamab
Black Box Warnings .
Cytokine Release Syndrome
including life-threatening or fatal reactions, occurred in 57% of patients; initiate tx using step-up dosing schedule for cycle 1; administer concomitant meds before and after infusion on day 1 and day 8 of cycle 1 to reduce CRS incidence and severity; administer at appropriate healthcare facility, monitor patients x22-24h post-infusion at facility on days 1 and 8 of cycle 1, recommend patients remain within 1h of facility with caregiver x48h after days 1 and 8 of cycle 1 infusions, then monitor signs/symptoms during tx and counsel patients to seek immediate medical attention if signs/symptoms of CRS occur; withhold tx until CRS resolves or permanently D/C tx based on severity
Neurological Toxicities
life-threatening or fatal reactions, including immune effector cell-associated neurotoxicity syndrome (ICANS) occurred in 65% of patients; may occur concurrently with CRS, after CRS resolution, or in the absence of CRS; monitor patients for signs/symptoms during tx and treat promptly; withhold tx until ICANS resolves or permanently D/C tx based on severity
Adult Dosing .
Dosage forms: INJ
Special Note
- [drug name clarification]
- Info: nonproprietary name = tarlatamab-dlle
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, concomitant meds, and dosing including toxicity-related dose adjustments
small cell lung CA, extensive-stage
- [10 mg IV x1 on days 1, 15 of 28-day cycle, starting cycle 2]
- Start: 1 mg IV x1 on day 1, then 10 mg IV x1 on day 8, then 10 mg IV x1 on day 15 of 28-day cycle for cycle 1; Info: for patients with disease progression on or after platinum-based chemo
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.