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Isovue
iopamidol
Black Box Warnings .
Risk w/ Inadvertent Intrathecal Administration
inadvertent intrathecal administration may cause death, convulsions, seizures, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, rhabdomyolysis, hyperthermia, and brain edema; for intra-arterial or IV use only
Adult Dosing .
Dosage forms: INJ: 200 mg per mL, 250 mg per mL, 300 mg per mL, 370 mg per mL
Special Note
- [strength clarification]
- Info: all strengths expressed as iodine concentration
- [formulation clarification]
- Info: not interchangeable w/ intrathecal iopamidol products; do not substitute on a mg to mg basis
cerebral arteriography
- [8-12 mL (300 mg per mL) intra-arterially x1]
- Max: cumulative dose 90 mL
peripheral arteriography
- [femoral artery or subclavian artery]
- Dose: 5-40 mL (300 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [aorta distal runoff]
- Dose: 25-50 mL (300 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
aortography and selective visceral arteriography
- [aortic arch or celiac artery]
- Dose: up to 50 mL (370 mg per mL) intra-arterially x1; Max: cumulative dose 225 mL
- [renal arteries]
- Dose: up to 10 mL (370 mg per mL) intra-arterially x1; Max: cumulative dose 225 mL
coronary arteriography
- [selective coronary artery]
- Dose: 2-10 mL (370 mg per mL) intra-arterially x1; Max: cumulative dose 200 mL
- [nonselective coronary arteries]
- Dose: 25-50 mL (370 mg per mL) intra-arterially x1; Max: cumulative dose 200 mL
cardiac ventriculography
- [25-50 mL (370 mg per mL) intra-arterially x1]
- Max: cumulative dose 200 mL
excretory urography
- [50-100 mL (250 mg per mL) IV x1]
- Alt: 50 mL (300 mg per mL) IV x1; 40 mL (370 mg per mL) IV x1
computed tomography
- [head]
- Dose: 130-240 mL (250 mg per mL) IV x1: Alt: 100-200 mL (300 mg per mL) IV x1
- [body]
- Dose: 130-240 mL (250 mg per mL) IV x1: Alt: 100-200 mL (300 mg per mL) IV x1; 80-160 mL (370 mg per mL) IV x1
peripheral venography
- [25-150 mL (200 mg per mL) IV x1 per leg]
- Max: 350 mL/total dose
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ: 200 mg per mL, 250 mg per mL, 300 mg per mL, 370 mg per mL
Special Note
- [strength clarification]
- Info: all strengths expressed as iodine concentration
- [formulation clarification]
- Info: not interchangeable w/ intrathecal iopamidol products; do not substitute on a mg to mg basis
angiocardiography
- [neonates]
- Dose: 0.5-2 mL/kg/dose (370 mg per mL) intra-arterially x1; Max: cumulative dose 5 mL/kg up to 40 mL
- [1-23 mo]
- Dose: 0.5-2 mL/kg/dose (370 mg per mL) intra-arterially x1; Max: cumulative dose 8 mL/kg up to 40 mL
- [2-4 yo]
- Dose: 0.5-2 mL/kg/dose (370 mg per mL) intra-arterially x1; Max: cumulative dose 8 mL/kg up to 50 mL
- [5-9 yo]
- Dose: 0.5-2 mL/kg/dose (370 mg per mL) intra-arterially x1; Max: cumulative dose 8 mL/kg up to 100 mL
- [10 yo and older]
- Dose: 0.5-2 mL/kg/dose (370 mg per mL) intra-arterially x1; Max: cumulative dose 8 mL/kg up to 125 mL
excretory urography
- [1.2-3.6 mL/kg/dose (250 mg per mL) IV x1]
- Alt: 1-3 mL/kg/dose (300 mg per mL) IV x1; Max: 120 mL/total dose (250 mg per mL); 100 mL/total dose (300 mg per mL)
computed tomography
- [head]
- Dose: 1.2-3.6 mL/kg/dose (250 mg per mL) IV x1; Alt: 1-3 mL/kg/dose (300 mg per mL) IV x1; Max: 120 mL/total dose (250 mg per mL); 100 mL/total dose (300 mg per mL)
- [body]
- Dose: 1.2-3.6 mL/kg/dose (250 mg per mL) IV x1; Alt: 1-3 mL/kg/dose (300 mg per mL) IV x1; Max: 120 mL/total dose (250 mg per mL); 100 mL/total dose (300 mg per mL)
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]