Voranigo

Adult Dosing .

Dosage forms:  TAB: 10 mg, 40 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

IDH1- or IDH2-positive astrocytoma, grade 2

[40 mg PO qd]

Info: for pts w/ prior surgery incl. biopsy, sub-total resection, or gross total resection; do not cut/crush/chew tab

IDH1- or IDH2-positive oligodendroglioma, grade 2

[40 mg PO qd]

Info: for pts w/ prior surgery incl. biopsy, sub-total resection, or gross total resection; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >40: no adjustment; CrCl <40: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  TAB: 10 mg, 40 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

IDH1- or IDH2-positive astrocytoma, grade 2

[12 yo and older, <40 kg]

Dose: 20 mg PO qd; Info: for pts w/ prior surgery incl. biopsy, sub-total resection, or gross total resection; do not cut/crush/chew tab

[12 yo and older, >40 kg]

Dose: 40 mg PO qd; Info: for pts w/ prior surgery incl. biopsy, sub-total resection, or gross total resection; do not cut/crush/chew tab

IDH1- or IDH2-positive oligodendroglioma, grade 2

[12 yo and older, <40 kg]

Dose: 20 mg PO qd; Info: for pts w/ prior surgery incl. biopsy, sub-total resection, or gross total resection; do not cut/crush/chew tab

[12 yo and older, >40 kg]

Dose: 40 mg PO qd; Info: for pts w/ prior surgery incl. biopsy, sub-total resection, or gross total resection; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >40: no adjustment; CrCl <40: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined