Polocaine

Adult Dosing .

Dosage forms:  INJ (1%): 10 mg per mL; INJ (1.5%): 15 mg per mL; INJ (2%): 20 mg per mL

Dosage Form Details

[formulation clarification]

Info: some concentrations methylparaben-free (MPF)

local anesthesia

[infiltration]

Dose: up to 400 mg/total dose (0.5% or 1%) via infiltration; Max: 400 mg/total dose; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

regional anesthesia

[peripheral nerve block, cervical]

Dose: 50-400 mg/total dose (1%) perineurally; Max: 400 mg/total dose; Alt: 100-400 mg/total dose (2%) perineurally; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[peripheral nerve block, brachial]

Dose: 50-400 mg/total dose (1%) perineurally; Max: 400 mg/total dose; Alt: 100-400 mg/total dose (2%) perineurally; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[peripheral nerve block, intercostal]

Dose: 50-400 mg/total dose (1%) perineurally; Max: 400 mg/total dose; Alt: 100-400 mg/total dose (2%) perineurally; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[peripheral nerve block, pudendal]

Dose: 25-200 mg (1%) perineurally x1 on each of 2 sides; Max: 400 mg/total dose; Alt: 50-200 mg (2%) perineurally x1 on each of 2 sides; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[peripheral nerve block, transvaginal]

Dose: up to 300 mg/total dose (1%) both sides perineurally; Max: 400 mg/total dose; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[peripheral nerve block, paracervical]

Dose: up to 200 mg/total dose (1%) both sides perineurally; Max: 400 mg/total dose; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[caudal block]

Dose: 150-300 mg/total dose (1% MPF) intracaudally; Max: 400 mg/total dose; Alt: 150-375 mg/total dose (1.5% MPF) intracaudally; 200-400 mg/total dose (2% MPF) intracaudally; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

[lumbar block]

Dose: 150-300 mg/total dose (1% MPF) epidurally; Max: 400 mg/total dose; Alt: 150-375 mg/total dose (1.5% MPF) epidurally; 200-400 mg/total dose (2% MPF) epidurally; Info: give epidural test dose before initial full dose and any repeat full doses; onset 3-5min, peak 15-45min, duration 0.75-1.5h

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ (1%): 10 mg per mL; INJ (1.5%): 15 mg per mL; INJ (2%): 20 mg per mL

Dosage Form Details

[formulation clarification]

Info: some concentrations preservative-free (MPF)

local anesthesia

[infiltration]

Dose: varies by procedure (0.5% or 1%); Max: 5-6 mg/kg/total dose; Info: onset 3-5min, peak 15-45min, duration 0.75-1.5h

regional anesthesia

[peripheral nerve block]

Dose: varies by procedure (1% or 2%); Max: 5-6 mg/kg/total dose; Info: avoid concentrations >1.5% if <3 yo or <13.6 kg; onset 3-5min, peak 15-45min, duration 0.75-1.5h

[caudal block]

Dose: varies by procedure (1% MPF, 1.5% MPF, or 2% MPF); Max: 5-6 mg/kg/total dose; Info: avoid concentrations >1.5% if <3 yo or <13.6 kg; onset 3-5min, peak 15-45min, duration 0.75-1.5h

[lumbar block]

Dose: varies by procedure (1% MPF, 1.5% MPF, or 2% MPF); Max: 5-6 mg/kg/total dose; Info: avoid concentrations >1.5% if <3 yo or <13.6 kg; give epidural test dose before initial full dose and any repeat full doses; onset 3-5min, peak 15-45min, duration 0.75-1.5h

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised