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Ziihera (zanidatamab-hrii)
zanidatamab
Black Box Warnings .
Embryo-Fetal Toxicity
exposure during pregnancy or w/in 4mo prior to conception can result in embryo-fetal harm, incl. oligohydramnios; advise pts of risks and need for effective contraception
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = zanidatamab-hrii
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
HER2-positive biliary tract CA, unresectable or metastatic
- [20 mg/kg/dose IV q2wk]
- Info: for pts w/ IHC3+ dz who have received prior tx
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.