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Symbravo
meloxicam/ rizatriptan
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 20 mg/10 mg
Special Note
- [formulation clarification]
- Info: not interchangeable w/ other meloxicam or rizatriptan products; do not substitute on a mg to mg basis
migraine, acute
- [1 tab PO x1]
- Max: 1 tab/day; Info: use shortest effective tx duration; do not cut/crush/chew tab
renal dosing
- [see below]
- moderate-severe impairment: avoid use; moderate-severe impairment w/ volume depletion: contraindicated
- HD: contraindicated; PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.