Vykat XR

Adult Dosing .

Dosage forms:  ER TAB: 25 mg, 75 mg, 150 mg

hyperphagia, Prader-Willi syndrome-associated

[40-64 kg]

Dose: 225 mg PO qd; Start: 75 mg PO qd x2wk, then 150 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[65-99 kg]

Dose: 375 mg PO qd; Start: 150 mg PO qd x2wk, then 225 mg PO qd x2wk, then 300 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[100-134 kg]

Dose: 450 mg PO qd; Start: 150 mg PO qd x2wk, then 300 mg PO qd x2wk, then 375 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[>135 kg]

Dose: 525 mg PO qd; Start: 150 mg PO qd x2wk, then 300 mg PO qd x2wk, then 450 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  ER TAB: 25 mg, 75 mg, 150 mg

hyperphagia, Prader-Willi syndrome-associated

[4 yo and older, 20-29 kg]

Dose: 100 mg PO qd; Start: 25 mg PO qd x2wk, then 50 mg PO qd x2wk, then 75 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 25 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[4 yo and older, 30-39 kg]

Dose: 150 mg PO qd; Start: 75 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[4 yo and older, 40-64 kg]

Dose: 225 mg PO qd; Start: 75 mg PO qd x2wk, then 150 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[4 yo and older, 65-99 kg]

Dose: 375 mg PO qd; Start: 150 mg PO qd x2wk, then 225 mg PO qd x2wk, then 300 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[4 yo and older, 100-134 kg]

Dose: 450 mg PO qd; Start: 150 mg PO qd x2wk, then 300 mg PO qd x2wk, then 375 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

[4 yo and older, >135 kg]

Dose: 525 mg PO qd; Start: 150 mg PO qd x2wk, then 300 mg PO qd x2wk, then 450 mg PO qd x2wk; Max: 5.8 mg/kg/day up to 525 mg/day; Info: if elevated fasting glucose, HbA1c or fluid overload, may interrupt tx or decr. dose, then incr. by up to 75 mg/day no more frequently than q2wk; retitrate if tx interrupted >7 days; do not cut/crush/chew tab

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]