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Rykindo
risperidone
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly patients on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: INJ: 12.5 mg per 2 mL, 25 mg per 2 mL, 37.5 mg per 2 mL, 50 mg per 2 mL
schizophrenia
- [25-50 mg IM q2wk]
- Start: 25 mg IM q2wk after establishing tolerability w/ oral risperidone, may incr. dose no more frequently than q4wk; Max: 50 mg IM q2wk; Info: overlap w/ oral risperidone x7 days; to switch from other q2wk IM risperidone form, start equivalent dose 4-5wk after last dose of prior tx; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, maintenance tx
- [25-50 mg IM q2wk]
- Start: 25 mg IM q2wk after establishing tolerability w/ oral risperidone, may incr. dose no more frequently than q4wk; Max: 50 mg IM q2wk; Info: for monotherapy or valproate or lithium adjunct; overlap w/ oral risperidone x7 days; to switch from other q2wk IM risperidone form, start equivalent dose 4-5wk after last dose of prior tx; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- renal impairment: use PO form to titrate; start 0.5 mg PO bid x1wk, then may incr. to 2 mg/day PO divided qd-bid x1wk, if tolerating then may add 12.5-25 mg IM q2wk; Info: D/C PO form 7 days after 1st IM dose
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: use PO form to titrate; start 0.5 mg PO bid x1wk, then may incr. to 2 mg/day PO divided qd-bid x1wk, if tolerating then may add 12.5-25 mg IM q2wk; Info: D/C PO form 7 days after 1st IM dose
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.