Avmapki Fakzynja Co-Pack

Adult Dosing .

Dosage forms:  28-DAY CYCLE PACK: avutometinib 0.8 mg CAP x24 and defactinib 200 mg TAB x42

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, prophylactic meds, and dosing incl. toxicity-related dose adjustments

KRAS-mutated low-grade serous ovarian CA, recurrent

[avutometinib 3.2 mg PO qd on days 1, 4, 8, 11, 15, 18 of 28-day cycle + defactinib 200 mg PO bid on days 1-21 of 28-day cycle]

Info: give w/ food; do not open avutometinib cap; do not cut/crush/chew defactinib tab

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST 1.1-2.5x ULN: no adjustment; bilirubin >1.5x ULN or AST >2.5x ULN: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.