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Grafapex
treosulfan
Black Box Warnings .
Myelosuppression
severe and prolonged myelosuppression occurs at recommended dose; HSCT required to prevent potentially fatal complications of prolonged myelosuppression
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, prophylactic regimens, and dosing incl. toxicity-related dose adjustments
AML, allogeneic HSCT conditioning tx
- [10 mg/m^2/dose IV qd on days -4, -3, -2 prior to transplantation]
- Max: 10 mg/m^2/day; 3 days; Info: use w/ fludarabine
MDS, allogeneic HSCT conditioning tx
- [10 mg/m^2/dose IV qd on days -4, -3, -2 prior to transplantation]
- Max: 10 mg/m^2/day; 3 days; Info: use w/ fludarabine
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl <60: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined
Peds Dosing .
- Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, prophylactic regimens, and dosing incl. toxicity-related dose adjustments
AML, allogeneic HSCT conditioning tx
- [1 yo and older]
- Dose: 10 mg/m^2/dose IV qd on days -4, -3, -2 prior to transplantation; Max: 10 mg/m^2/day; 3 days; Info: use w/ fludarabine
MDS, allogeneic HSCT conditioning tx
- [1 yo and older]
- Dose: 10 mg/m^2/dose IV qd on days -4, -3, -2 prior to transplantation; Max: 10 mg/m^2/day; 3 days; Info: use w/ fludarabine
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl <60: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined