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Vanrafia
atrasentan
Black Box Warnings .
Embryo-Fetal Toxicity
contraindicated in pregnancy; major birth defect risk if used during pregnancy based on animal data; exclude pregnancy before tx start and use effective contraception before tx start, during tx, and x2wk after D/C; D/C tx if patient becomes pregnant
Adult Dosing .
Dosage forms: TAB: 0.75 mg
IgA nephropathy, primary
- [0.75 mg PO qd]
- Info: for patients w/ rapid progression risk; do not cut/crush/chew tab
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid tx initiation
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.