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Mezofy
aripiprazole
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly patients on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in patients >24 yo, and risk decr. in patients 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all patients for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for depression in peds patients
Adult Dosing .
Dosage forms: STRIP: 5 mg, 10 mg, 15 mg
schizophrenia
- [10-15 mg PO qd]
- Start: 10-15 mg PO qd; may incr. dose q2wk; Max: 30 mg/day; Info: doses >15 mg/day rarely more effective; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew/swallow strip; may use other oral aripiprazole products for dose adjustments
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: STRIP: 5 mg, 10 mg, 15 mg
schizophrenia
- [13-17 yo]
- Dose: 10 mg PO qd; Start: 2 mg PO qd x2 days, then 5 mg PO qd x2 days, then incr. dose in 5 mg increments; Max: 30 mg/day; Info: doses >10 mg/day rarely more effective; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew/swallow strip; 2 mg strip form not avail. for this brand, may use other oral aripiprazole products for start dose and dose adjustments
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]