Javadin

Adult Dosing .

Dosage forms:  SOLUTION: 0.02 mg per mL

HTN

[0.1-0.8 mg/day PO divided bid]

Start: 0.1 mg PO bid, may incr. by 0.1 mg/day qwk; Max: 2.4 mg/day; Info: consider lower start dose in elderly patients; if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

Tourette syndrome (off-label)

[0.1-0.3 mg/day PO divided bid-qid]

Start: 0.025-0.05 mg PO qd, then may titrate slowly; Max: 0.6 mg/day; Info: if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

opioid withdrawal (off-label)

[0.1-0.3 mg PO tid-qid]

Start: 0.1-0.2 mg PO bid-qid; Max: 1.2 mg/day; Info: adjust dose based on clinical response and adverse effects; hold tx if BP <90/60; taper dose gradually to D/C approximately 7-10 days after opioid cessation

renal dosing

[see below]

renal impairment: consider decr. usual start dose, titrate slowly

HD: consider decr. usual start dose, titrate slowly; no supplement after dialysis; PD: consider decr. usual start dose, titrate slowly; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  SOLUTION: 0.02 mg per mL

ADHD (off-label)

[27-40.5 kg]

Dose: 0.003-0.005 mg/kg/day PO divided tid-qid; Start: 0.05 mg PO qhs, then may incr. by 0.05 mg/day q3-7 days; Max: 0.05 mg/dose up to 0.2 mg/day; Info: if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

[40.5-45 kg]

Dose: 0.003-0.005 mg/kg/day PO divided tid-qid; Start: 0.05 mg PO qhs, then may incr. by 0.05 mg/day q3-7 days; Max: 0.1 mg/dose up to 0.3 mg/day; Info: if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

[>45 kg]

Dose: 0.003-0.005 mg/kg/day PO divided tid-qid; Start: 0.1 mg PO qhs, then may incr. by 0.1 mg/day q3-7 days; Max: 0.1 mg/dose up to 0.4 mg/day; Info: if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

HTN (off-label)

[12 yo and older]

Dose: 0.2-0.8 mg/day PO divided bid; Start: 0.2 mg/day PO divided bid, may incr. by 0.1 mg/day qwk; Max: 2.4 mg/day; Info: if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

HTN, acute severe (off-label)

[0.05-0.1 mg PO q1h prn]

Max: 0.8 mg/total dose; 8h; Info: for patients with non-life-threatening symptoms

Tourette syndrome (off-label)

[7 yo and older]

Dose: 0.1-0.3 mg/day PO divided bid-qid; Start: 0.025-0.05 mg PO qd, then may titrate slowly; Max: 0.4 mg/day; Info: if divided doses unequal, give larger dose in evening; taper dose over 2-4 days to D/C

neonatal opioid withdrawal syndrome, adjunct tx (off-label)

[0.5-1 mcg/kg/dose PO q3-6h]

Max: 8 mcg/kg/day; Info: refer to institutional protocol

renal dosing

[see below]

renal impairment: consider decr. usual start dose, titrate slowly

HD: consider decr. usual start dose, titrate slowly; no supplement after dialysis; PD: consider decr. usual start dose, titrate slowly; no supplement

hepatic dosing

[not defined]