Theo-24

Adult Dosing .

Dosage forms:  ER CAP: 100 mg, 200 mg, 300 mg, 400 mg

COPD, maintenance tx

[individualize dose PO qam]

Start: 300-400 mg PO qam x3 days, then may incr. to 400-600 mg PO qam; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q12h and give 2nd dose before evening meal 10-12h after 1st dose; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; take high doses (>900 mg/dose) >1h before high fat-containing meals

asthma, maintenance tx

[individualize dose PO qam]

Start: 300-400 mg PO qam x3 days, then may incr. to 400-600 mg PO qam; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q12h and give 2nd dose before evening meal 10-12h after 1st dose; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; take high doses (>900 mg/dose) >1h before high fat-containing meals

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual dose, amount not defined

Peds Dosing .

asthma, maintenance tx

[12-15 yo, <45 kg]

Dose: individualize dose PO qam; Start: 12-14 mg/kg/day up to 300 mg PO qam x3 days, then may incr. to 16 mg/kg/day up to 400 mg PO qam, then may incr. to 20 mg/kg/day up to 600 mg PO qam; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose; in rapid metabolizers divide total daily dose q12h and give 2nd dose before evening meal 10-12h after 1st dose; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; take high doses (>13 mg/kg/dose or >900 mg/dose) >1h before high fat-containing meals

[12 yo and older, >45 kg]

Dose: individualize dose PO qam; Start: 300-400 mg PO qam x3 days, then may incr. to 400-600 mg PO qam; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q12h and give 2nd dose before evening meal 10-12h after 1st dose; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; take high doses (>900 mg/dose) >1h before high fat-containing meals

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual dose, amount not defined