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dacarbazine
generic
Black Box Warnings .
Appropriate Use
admin. only under supervision of physician experienced in cancer chemotherapy; weigh possible therapeutic benefit vs. risk of toxicity for each patient
Myelosuppression
most common toxicity
Hepatotoxicity
hepatic necrosis reported
Carcinogen/Teratogen
carcinogenic and teratogenic in animal studies
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
melanoma, metastatic
- [2-4.5 mg/kg/dose IV x1 on days 1-10 of 28-day cycle]
- Alt: 250 mg/m^2/dose IV x1 on days 1-5 of 21-day cycle
Hodgkin lymphoma
- [150 mg/m^2/dose IV x1 on days 1-5 of 28-day cycle]
- Alt: 375 mg/m^2/dose IV x1 on day 1 of 15-day cycle; Info: part of multi-drug chemo regimen
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.