fludarabine

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

CLL

[first-line tx, combo tx]

Dose: 25 mg/m^2/dose IV x1 on days 1-3 of 28-day cycle x6 cycles

[progressive disease, monotherapy]

Dose: 25 mg/m^2/dose IV x1 on days 1-5 of 28-day cycle

allogeneic HSCT conditioning tx (off-label)

[AML]

Dose: 30 mg/m^2/dose IV q24h on days -6, -5, -4, -3, -2 prior to transplantation; Info: use with treosulfan

[MDS]

Dose: 30 mg/m^2/dose IV q24h on days -6, -5, -4, -3, -2 prior to transplantation; Info: use with treosulfan

lymphodepleting tx (off-label)

[individulize dose IV x1 on specific day(s) per regimen]

Start: prior to T-cell immunotherapy; Info: use with cyclophosphamide

renal dosing

[see below]

CrCl 50-79: decr. usual dose by 20%; CrCl 30-49: decr. usual dose by 40%; CrCl <30: not defined

HD: decr. usual dose by 50-75%, on dialysis days administer after dialysis; no supplement; PD: decr. usual dose by 50%; supplement not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

ALL (off-label)

[1 yo and older]

Dose: 10.5 mg/m^2/dose IV x1 on day 1, then 30.5 mg/m^2/24h IV infusion x5 days

solid tumor (off-label)

[1 yo and older]

Dose: 7 mg/m^2/dose IV x1 on day 1, then 20 mg/m^2/24h IV infusion x5 days

allogeneic HSCT conditioning tx (off-label)

[AML, 1 yo and older]

Dose: 30 mg/m^2/dose IV q24h on days -6, -5, -4, -3, -2 prior to transplantation; Info: use with treosulfan

[MDS, 1 yo and older]

Dose: 30 mg/m^2/dose IV q24h on days -6, -5, -4, -3, -2 prior to transplantation; Info: use with treosulfan

lymphodepleting tx (off-label)

[individulize dose IV x1 on specific day(s) per regimen]

Start: prior to T-cell immunotherapy; Info: use with cyclophosphamide

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]