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Idamycin PFS
idarubicin
Black Box Warnings .
Appropriate Use
admin. only by physicians trained in leukemia chemotherapy in adequate medical facility incl. monitor drug tolerance, protect and maintain pt compromised by drug toxicity, and rapid and complete response to severe hemorrhagic conditions and/or overwhelming infection
Cardiotoxicity
myocardial toxicity leading to CHF may occur; more common if prior anthracycline tx or pre-existing cardiac dz
Extravasation
can result in severe local tissue necrosis; give slowly into freely flowing IV infusion, never give IM or SC
Myelosuppression
severe myelosuppression may occur
Renal or Hepatic Impairment
decr. dose if hepatic or renal impairment
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
AML, induction
- [12 mg/m^2/dose IV x1 on days 1-3 of cycle]
- Info: use w/ cytarabine; may give 2nd course if unequivocal evidence of leukemia after 1st course
renal dosing
- [adjust dose amount]
- CrCl 10-50: decr. usual dose by 25%; CrCl <10: decr. usual dose by 50%
- HD: decr. usual dose by 50%; no supplement after dialysis; PD: decr. usual dose by 50%; no supplement
hepatic dosing
- [see below]
- bilirubin 2.6-5: decr. usual dose by 50%; bilirubin >5: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.