Profilnine SD

Adult Dosing .

Dosage forms:  INJ

hemophilia B

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 20-40%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-80%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-80%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ

hemophilia B

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 20-40%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-80%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-80%; 1 unit/kg will incr. factor IX level approx. 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised