Carnitor

Adult Dosing .

Dosage forms:  TAB: 330 mg; SOL: 100 mg per mL; INJ: various

carnitine deficiency

[primary]

Dose: 990 mg PO bid-tid; Start: 330 mg PO tid, incr. gradually; Alt: start 1 g/day solution PO divided q3-4h, then may incr. gradually to 1-3 g/day PO divided q3-4h; Info: give oral solution slowly w/ or after meals if GI intolerance

[secondary, PO route]

Dose: 990 mg PO bid-tid; Start: 330 mg PO tid, incr. gradually; Alt: start 1 g/day solution PO divided q3-4h, then may incr. gradually to 1-3 g/day PO divided q3-4h; Info: give oral solution slowly w/ or after meals if GI intolerance

[secondary, IV route]

Dose: 50 mg/kg/day IV divided q3-6h; Max: 300 mg/kg/day; Info: if severe metabolic crisis, start 50 mg/kg/dose IV x1, then 50 mg/kg/day IV divided q3-6h

[hemodialysis-associated]

Dose: 5-40 mg/kg/dose IV after each HD session; Start: 10-20 mg/kg/dose IV after each HD session; Info: dose based on dry body wt; initiate tx/adjust dose based on trough free plasma carnitine levels

renal dosing

[PO route]

mild-moderate impairment: not defined; severe impairment: not defined, caution advised w/ high-dose use

HD/PD: not defined, caution advised w/ high-dose use

[IV route]

renal impairment: not defined

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 330 mg; SOL: 100 mg per mL; INJ: various

carnitine deficiency

[primary]

Dose: 50-100 mg/kg/day PO in divided doses; Start: 50 mg/kg/day, incr. gradually; Max: 3 g/day; Info: divide dose q8-12h if using tablets, q3-4h if using solution; give oral solution slowly w/ or after meals if GI intolerance

[secondary, PO route]

Dose: 50-100 mg/kg/day PO in divided doses; Start: 50 mg/kg/day, incr. gradually; Max: 3 g/day; Info: divide dose q8-12h if using tablets, q3-4h if using solution; give oral solution slowly w/ or after meals if GI intolerance

[secondary, IV route]

Dose: 50 mg/kg/day IV divided q3-6h; Max: 300 mg/kg/day; Info: if severe metabolic crisis, start 50 mg/kg/dose IV x1, then 50 mg/kg/day IV divided q3-6h

[hemodialysis-assoc.]

Dose: 5-40 mg/kg/dose IV after each HD session; Start: 10-20 mg/kg/dose IV after each HD session; Info: dose based on dry body wt; initiate tx/adjust dose based on trough free plasma carnitine levels

cyclic vomiting syndrome prophylaxis, adjunct tx (off-label)

[2 yo and older]

Dose: 50-100 mg/kg/day PO in divided doses; Max: 3 g/day; Info: divide dose q8-12h if using tablets, q3-4h if using solution; give oral solution slowly w/ or after meals if GI intolerance

renal dosing

[PO route]

mild-moderate impairment: not defined; severe impairment: not defined, caution advised w/ high-dose use

HD/PD: not defined, caution advised w/ high-dose use

[IV route]

renal impairment: not defined

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[not defined]