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Migranal
dihydroergotamine nasal
Black Box Warnings .
Peripheral Ischemia w/ Concomitant Strong CYP3A4 Inhibitor Use
serious and/or life-threatening peripheral ischemia possible when given in combo w/ strong CYP3A4 inhibitors incl. protease inhibitors and macrolide antibiotics; CYP3A4 inhibition incr. serum levels and risk for vasospasm leading to cerebral ischemia and/or ischemia of extremities; concomitant use w/ strong CYP3A4 inhibitors contraindicated
Adult Dosing .
Dosage forms: SPRAY: 0.5 mg per actuation
migraine, acute
- [1 actuation in each nostril q15min x2]
- Max: 4 actuations/attack; Info: safety not established w/ doses >6 actuations/day or >8 actuations/wk
renal dosing
- [see below]
- mild-moderate impairment: not defined; severe impairment: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- severe impairment: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.