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diflunisal
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 250 mg, 500 mg
pain, mild-moderate
- [500 mg PO q12h]
- Start: 1000 mg PO x1; Max: 1500 mg/day; Alt: 250-500 mg PO q8-12h; Info: use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab
osteoarthritis
- [250-500 mg PO q12h]
- Max: 1500 mg/day; Info: use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab
rheumatoid arthritis
- [250-500 mg PO q12h]
- Max: 1500 mg/day; Info: use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab
renal dosing
- [see below]
- renal impairment: not defined, caution advised; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.