Tazicef

Adult Dosing .

Dosage forms:  INJ

infections, bacterial

[1-2 g IV q8-12h]

Max: 6 g/day

pneumonia, hospital-acquired or ventilator-associated

[2 g IV q8h x7 days]

Info: may extend duration based on clinical response; refer to IDSA guidelines

meningitis, healthcare-associated

[2 g IV q8h x10-14 days]

Info: may extend duration based on clinical and microbiologic response

febrile neutropenia (off-label)

[2 g IV q8h until resolution of neutropenia]

Info: re-evaluate duration frequently if neutropenic >7 days

endophthalmitis, bacterial (off-label)

[2.25 mg in 0.1 mL sterile water or saline intravitreally x1]

Info: part of multi-drug regimen; refer to institution protocol; may repeat q48h x1

renal dosing

[intravitreal route]

renal impairment: not defined

HD/PD: not defined

[IV route]

CrCl 31-50: give usual dose IV q12h; CrCl 16-30: give usual dose IV q24h; CrCl 6-15: give usual dose IV x1, then give 50% usual dose IV q24h; CrCl <5: give usual dose IV x1, then give 50% usual dose IV q48h

HD: 1 g IV x1, then 1 g IV 3x/wk after dialysis; consider supplement if next maintenance dose not due right after dialysis; Alt: 0.5-1 g IV q24h, on dialysis days admin. after dialysis; consider 1 g IV supplement if next maintenance dose not due right after dialysis; PD: 1 g IV x1, then 500 mg IV q24h; supplement not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

infections, bacterial

[neonates 0-7 days old]

Dose: 100 mg/kg/day IV divided q12h

[neonates >7 days old, <1200 g]

Dose: 100 mg/kg/day IV divided q12h

[neonates >7 days old, >1200 g]

Dose: 150 mg/kg/day IV divided q8h

[1 mo and older]

Dose: 90-150 mg/kg/day IV divided q8h; Max: 6 g/day; Info: reserve high dose for immunocompromised, cystic fibrosis, or meningitis

meningitis, healthcare-associated

[150-200 mg/kg/day IV divided q6-8h x 10-14 days]

Max: 6 g/day; Info: may extend duration based on clinical and microbiologic response

febrile neutropenia (off-label)

[1 mo and older]

Dose: 50 mg/kg/dose IV q8h until resolution of neutropenia; Max: 2 g/dose; Info: re-evaluate duration frequently if neutropenic >7 days

endophthalmitis, bacterial (off-label)

[2 yo and older]

Dose: 2.25 mg in 0.1 mL sterile water or saline intravitreally x1; Info: part of multi-drug regimen; refer to institution protocol; may repeat q48h x1

renal dosing

[intravitreal route]

renal impairment: not defined

HD/PD: not defined

[IV route]

CrCl 30-50: give usual divided dose IV q12h; CrCl 10-29: give usual divided dose IV q24h; CrCl <10: give usual divided dose IV x1, then give 50% usual divided dose IV q24h

HD: give usual divided dose IV x1, then give 50% usual divided dose IV q24h, on dialysis days admin. after dialysis; consider supplement if next maintenance dose not due right after dialysis; PD: give usual divided dose IV x1, then give 50% usual divided dose IV q24h; supplement not defined

hepatic dosing

[no adjustment]