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vinblastine
generic
Black Box Warnings .
Appropriate Use
give only by individuals experienced w/ vinblastine admin; for IV use only, fatal if given intrathecally; vinblastine extravasation during IV admin. may cause considerable irritation, if extravasation occurs immediately D/C injection and give remaining dose via another vein; see pkg insert for extravasation mgmt
Intrathecal Use Contraindicated
must label syringes w/ Fatal if Given Intrathecally, for Intravenous Use Only; need immediate neurosurgical intervention after accidental intrathecal admin. to attempt prevention of ascending paralysis leading to death, see pkg insert
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
Hodgkin lymphoma
- [6 mg/m^2/dose IV x1 on days 1, 15 of 28-day cycle]
- Max: 18.5 mg/m^2; Info: part of multi-drug chemo regimen
testicular CA
- [0.11 mg/kg/dose IV x1 on days 1-2 of 21-day cycle]
- Info: part of multi-drug chemo regimen
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [adjust dose amount]
- bilirubin >3: decr. usual dose by 50%
Peds Dosing .
- Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
Hodgkin lymphoma
- [6 mg/m^2/dose IV x1 on days 1, 15 of 28-day cycle]
- Info: part of multi-drug chemo regimen
testicular CA
- [0.11 mg/kg/dose IV x1 on days 1-2 of 21-day cycle]
- Info: part of multi-drug chemo regimen
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance