desflurane inhaled

Adult Dosing .

Dosage forms:  VOLATILE LIQUID

general anesthesia induction

[MAC in 100% oxygen]

Dose: individualize dose; Start: 3%, incr. by 0.5-1% q2-3 breaths prn; Info: cough/excitation may limit induction speed; end tidal conc. 4-11% produces surgical anesthesia x2-4min; MAC in 25 yo = 7.3%, in 45 yo = 6%, in 70 yo = 5.2%; blood/gas partition coefficient (37C) = 0.42

[MAC in 60% nitrous oxide/40% oxygen]

Dose: individualize dose; Start: 3%, incr. by 0.5-1% q2-3 breaths prn; Info: cough/excitation may limit induction speed; end tidal conc. 4-11% produces surgical anesthesia x2-4min; MAC in 25 yo = 4%, in 45 yo = 2.8%, in 70 yo = 1.7%; blood/gas partition coefficient (37C) = 0.42

general anesthesia maintenance

[MAC in 100% oxygen]

Dose: individualize dose, typical range 2.5-8.5%; Info: titrate inhalation to effect; MAC in 25 yo = 7.3%, in 45 yo = 6%, in 70 yo = 5.2%; blood/gas partition coefficient (37C) = 0.42

[MAC in 60% nitrous oxide/40% oxygen]

Dose: individualize dose, typical range 2.5-8.5%; Info: titrate inhalation to effect; MAC in 25 yo = 4%, in 45 yo = 2.8%, in 70 yo = 1.7%; blood/gas partition coefficient (37C) = 0.42

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  VOLATILE LIQUID

general anesthesia maintenance

[intubated pts, MAC in 100% oxygen]

Dose: individualize dose, typical range 5.2-10%; Info: titrate inhalation to effect; MAC in 2 wk old = 9.2%, in 10 wk old = 9.4%, in 9 mo = 10%, in 2 yo = 9.1%, in 4 yo = 8.6%, in 7 yo =8.1%; blood/gas partition coefficient (37C) = 0.42

[intubated pts, MAC in 60% nitrous oxide/40% oxygen]

Dose: individualize dose, typical range 5.2-10%; Info: titrate inhalation to effect; MAC in 9 mo = 7.5%, in 3 yo = 6.4%; blood/gas partition coefficient (37C) = 0.42

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]