sevoflurane inhaled

Adult Dosing .

Dosage forms:  VOLATILE LIQUID

general anesthesia induction

[individualize dose]

Info: titrate inhalation to effect; blood/gas partition coefficient (37C) = 0.63-0.69

general anesthesia maintenance

[MAC in 100% oxygen]

Dose: individualize dose, typical range 0.5-3%; Info: titrate inhalation to effect; MAC in 25 yo = 2.6%, in 40 yo = 2.1%, in 60 yo = 1.7%, in 80 yo = 1.4%; blood/gas partition coefficient (37C) = 0.63-0.69

[MAC in 65% nitrous oxide/35% oxygen]

Dose: individualize dose, typical range 0.5-3%; Info: titrate inhalation to effect; MAC in 25 yo = 1.4%, in 40 yo = 1.1%, in 60 yo = 0.9%, in 80 yo = 0.7%; blood/gas partition coefficient (37C) = 0.63-0.69

renal dosing

[see below]

renal impairment: not defined; Info: caution advised if Cr >1.5

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Dosage forms:  VOLATILE LIQUID

general anesthesia induction

[individualize dose]

Info: titrate inhalation to effect; blood/gas partition coefficient (37C) = 0.63-0.69

general anesthesia maintenance

[MAC in 100% oxygen]

Dose: individualize dose, typical range 0.5-3%; Info: titrate inhalation to effect; MAC in 0-1 mo = 3.3%, in 1-5 mo = 3%, in 6 mo-2 yo = 2.8%, in 3-12 yo = 2.5%; blood/gas partition coefficient (37C) = 0.63-0.69

[MAC in 65% nitrous oxide/35% oxygen]

Dose: individualize dose, typical range 0.5-3%; Info: titrate inhalation to effect; MAC in 6 mo-2 yo = 2%; blood/gas partition coefficient (37C) = 0.63-0.69

[MAC in 60% nitrous oxide/40% oxygen]

Dose: individualize dose, typical range 0.5-3%; Info: titrate inhalation to effect; MAC in 1-2 yo = 2%; blood/gas partition coefficient (37C) = 0.63-0.69

renal dosing

[see below]

renal impairment: not defined; Info: caution advised if Cr >1.5

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined