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mexiletine
generic
Black Box Warnings .
Increased Mortality
excessive mortality or nonfatal cardiac arrest rate (7.7% encainide/flecainide vs. 3% placebo) in asymptomatic non-life-threatening ventricular arrhythmias w/ MI 6 days - 2 years prior; restrict use to life-threatening ventricular arrhythmias, no survival benefit in pts w/o life-threatening arrhythmias
Adult Dosing .
Dosage forms: CAP: 150 mg, 200 mg, 250 mg
ventricular arrhythmias
- [200 mg PO q8h]
- Alt: 450 mg PO q12h; Info: rarely indicated, consult cardiologist
neuropathic pain, diabetic (off-label)
- [10 mg/kg/dose PO qd]
- Start: 150 mg PO qd x3 days then 300 mg PO qd x3 days then 10 mg/kg/dose PO qd; Info: not 1st-line tx
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement
hepatic dosing
- [adjust dose amount]
- hepatic impairment: decr. usual dose, amount not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.