Nesacaine

Adult Dosing .

Dosage forms:  INJ (1%): 10 mg per mL; INJ (2%): 20 mg per mL; INJ (3%): 30 mg per mL

Special Note

[formulation clarification]

Info: some concentrations methylparaben-free (MPF)

local anesthesia

[infiltration, mandibular]

Dose: 40-60 mg (2%) via infiltration x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[infiltration, infraorbital]

Dose: 10-20 mg (2%) via infiltration x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[infiltration, digital]

Dose: 30-40 mg (1%) via infiltration x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

regional anesthesia

[peripheral nerve block, mandibular]

Dose: 40-60 mg (2%) perineurally x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[peripheral nerve block, infraorbital]

Dose: 10-20 mg (2%) perineurally x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[peripheral nerve block, digital]

Dose: 30-40 mg (1%) perineurally x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[peripheral nerve block, brachial plexus]

Dose: 600-800 mg (2%) perineurally x1; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[peripheral nerve block, pudendal]

Dose: 200 mg (2%) perineurally x1 on each of 2 sides; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[peripheral nerve block, paracervical]

Dose: 30 mg (1%) perineurally x1 on each of 4 sites; Max: 11 mg/kg/dose, 800 mg/total dose; Info: onset 6-12min, duration up to 60min

[caudal block]

Dose: 300-500 mg (2% MPF) intracaudally x1; Max: 11 mg/kg/dose, 800 mg/total dose; Alt: 450-750 mg (3% MPF) intracaudally x1; Info: onset 6-12min, duration up to 60min; see pkg insert for repeat doses

[lumbar block]

Dose: 40-50 mg (2% MPF) epidurally x1 per segment; Max: 11 mg/kg/dose, 800 mg/total dose; Alt: 60-75 mg (3% MPF) epidurally x1 per segment; Info: onset 6-12min, duration up to 60min; see pkg insert for repeat doses

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ (1%): 10 mg per mL; INJ (2%): 20 mg per mL; INJ (3%): 30 mg per mL

Special Note

[formulation clarification]

Info: some concentrations methylparaben-free (MPF)

local anesthesia

[infiltration]

Dose: varies by procedure (0.5-1%); Info: max 11 mg/kg/dose in pts >3 yo; onset 6-12min, duration up to 60min

regional anesthesia

[peripheral nerve block]

Dose: varies by procedure (1-1.5%); Info: max 11 mg/kg/dose in pts >3 yo; onset 6-12min, duration up to 60min

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised