Select a medication above to begin.
theophylline
generic
Adult Dosing .
Dosage forms: ER TAB (12h): 100 mg, 200 mg, 300 mg, 450 mg; ER TAB (24h): 400 mg, 600 mg; SOL: 80 mg per 15 mL
COPD, maintenance tx
- [24h extended-release tab form]
- Dose: individualize dose ER PO q24h; Start: 300-400 mg ER PO q24h x3 days, then may incr. to 400-600 mg ER PO q24h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q12h; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [12h extended-release tab form]
- Dose: individualize dose ER PO q12h; Start: 300 mg/day ER PO divided q12h x3 days, then may incr. to 400 mg/day ER PO divided q12h x3 days, then may incr. to 600 mg ER PO divided q12h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q8h; may switch to q24h dosing if stable on lower total daily doses q12h; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [oral solution form]
- Dose: individualize dose PO q6-8h; Start: 300 mg/day PO divided q6-8h x3 days, then may incr. to 400 mg/day PO divided q6-8h x3 days, then may incr. to 600 mg/day PO divided q6-8h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose more frequently; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism
asthma, maintenance tx
- [24h extended-release tab form]
- Dose: individualize dose ER PO q24h; Start: 300-400 mg ER PO q24h x3 days, then may incr. to 400-600 mg ER PO q24h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q12h; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [12h extended-release tab form]
- Dose: individualize dose ER PO q12h; Start: 300 mg/day ER PO divided q12h x3 days, then may incr. to 400 mg/day ER PO divided q12h x3 days, then may incr. to 600 mg ER PO divided q12h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q8h; may switch to q24h dosing if stable on lower total daily doses q12h; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [oral solution form]
- Dose: individualize dose PO q6-8h; Start: 300 mg/day PO divided q6-8h x3 days, then may incr. to 400 mg/day PO divided q6-8h x3 days, then may incr. to 600 mg/day PO divided q6-8h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose more frequently; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: decr. usual dose, amount not defined
Peds Dosing .
- Dosage forms: ER TAB (12h): 100 mg, 200 mg, 300 mg, 450 mg; ER TAB (24h): 400 mg, 600 mg; SOL: 80 mg per 15 mL
asthma, maintenance tx
- [oral solution form, premature neonates, <24 days old]
- Dose: individualize dose PO q12h; Start: 1 mg/kg/dose PO q12h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose
- [oral solution form, premature neonates, 24 days old and older]
- Dose: individualize dose PO q12h; Start: 1.5 mg/kg/dose PO q12h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose
- [oral solution form, full term neonates or infants up to 26 wk old]
- Dose: individualize dose PO q8h; Start: ((0.2 x age [wk]) + 5) x wt [kg] = mg/day PO divided q8h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose
- [oral solution form, 26-52 wk old]
- Dose: individualize dose PO q6h; Start: ((0.2 x age [wk]) + 5) x wt [kg] = mg/day PO divided q6h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose
- [oral solution form, 1-15 yo, <45 kg]
- Dose: individualize dose PO q4-6h; Start: 12-14 mg/kg/day up to 300 mg PO divided q4-6h x3 days, then may incr. to 16 mg/kg/day up to 400 mg PO divided q4-6h x3 days, then may incr. to 20 mg/kg/day up to 600 mg PO divided q4-6h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose; in rapid metabolizers divide total daily dose more frequently; max 16 mg/kg/day up to 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism
- [oral solution form, 1 yo and older, >45 kg]
- Dose: individualize dose PO q6-8h; Start: 300 mg PO divided q6-8h x3 days, then may incr. to 400 mg PO divided q6-8h x3 days, then may incr. to 600 mg PO divided q6-8h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose more frequently; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism
- [12h extended-release tab form, 6-15 yo, <45 kg]
- Dose: individualize dose ER PO q12h; Start: 12-14 mg/kg/day up to 300 mg/day ER PO divided q12h x3 days, then may incr. to 16 mg/kg/day up to 400 mg/day ER PO divided q12h x3 days, then may incr. to 20 mg/kg/day up to 600 mg ER PO divided q12h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose; in rapid metabolizers divide total daily dose q8h; may switch to q24h dosing if stable on lower total daily doses q12h; max 16 mg/kg/day up to 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [12h extended-release tab form, 6 yo and older, >45 kg]
- Dose: individualize dose ER PO q12h; Start: 300 mg/day ER PO divided q12h x3 days, then may incr. to 400 mg/day ER PO divided q12h x3 days, then may incr. to 600 mg ER PO divided q12h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q8h; may switch to q24h dosing if stable on lower total daily doses q12h; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [24h extended-release tab form, 12-15 yo, <45 kg]
- Dose: individualize dose ER PO q24h; Start: 12-14 mg/kg/day up to 300 mg/day ER PO q24h x3 days, then may incr. to 16 mg/kg/day up to 400 mg/day ER PO q24h x3 days, then may incr. to 20 mg/kg/day up to 600 mg ER PO q24h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose; in rapid metabolizers divide total daily dose q12h; max 16 mg/kg/day up to 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
- [24h extended-release tab form, 12 yo and older, >45 kg]
- Dose: individualize dose ER PO q24h; Start: 300-400 mg ER PO q24h x3 days, then may incr. to 400-600 mg ER PO q24h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose q12h; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism; give consistently w/ food or on empty stomach; do not crush/chew ER tab, but may split ER tab
apnea of prematurity (off-label)
- [3-6 mg/kg/day PO divided q6-8h]
- Start: 5 mg/kg/dose PO x1; Info: adjust dose based on serum levels
renal dosing
- [0-3 mo]
- renal impairment: decr. usual dose, amount not defined
- HD/PD: not defined
- [>3 mo]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: decr. usual dose, amount not defined