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Elitek
rasburicase
Black Box Warnings .
Hypersensitivity Rxn
serious and fatal hypersensitivity rxns incl. anaphylaxis; immediately and permanently D/C tx if clinical evidence of serious hypersensitivity rxn
Hemolysis
can cause severe hemolysis in G6PD deficiency; immediately and permanently D/C tx in any pt w/ hemolysis; screen high risk G6PD deficiency pts incl. African or Mediterranean descent prior to use
Methemoglobinemia
immediately and permanently D/C tx if methemoglobinemia
Uric Acid Test Interference
enzymatic degradation of uric acid in blood samples left at room temp resulting in spuriously low uric acid levels; collect blood in pre-chilled tubes w/ heparin, immediately immerse and maintain in ice water bath, and assay sample w/in 4h of collection
Adult Dosing .
Dosage forms: INJ
hyperuricemia, chemo-related
- [0.2 mg/kg/dose IV qd for up to 5 days]
- Info: screen pts of African or Mediterranean ancestry for G6PD deficiency before initiating tx
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
hyperuricemia, chemo-related
- [0.2 mg/kg/dose IV qd for up to 5 days]
- Info: screen pts of African or Mediterranean ancestry for G6PD deficiency before initiating tx
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]