Select a medication above to begin.
Hepsera
adefovir dipivoxil
Black Box Warnings .
Hepatitis B Exacerbation
severe acute hepatitis exacerbations reported when D/C anti-HBV tx including adefovir; monitor hepatic function closely for at least several months if D/C tx; resume anti-HBV tx if needed
Nephrotoxicity
chronic adefovir administration may cause nephrotoxicity in patients at risk or with underlying renal impairment; closely monitor renal function, adjust dose as needed
HIV Resistance
HIV resistance may emerge in chronic HBV patients with untreated or unrecognized HIV when given anti-HBV tx including adefovir that may have activity against HIV
Lactic Acidosis/Severe Hepatomegaly with Steatosis
lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, associated with nucleoside analog use alone or in combination; incr. risk if female, obese, or long-term nucleoside analog tx; suspend tx if clinical or laboratory findings suggest lactic acidosis or hepatotoxicity
Adult Dosing .
Dosage forms: TAB: 10 mg
hepatitis B infection, chronic
- [10 mg PO qd]
- Info: use in combo with lamivudine, not as adefovir monotherapy if lamivudine resistant HBV
renal dosing
- [adjust dose frequency]
- CrCl 30-49: give usual dose q48h; CrCl 10-29: give usual dose q72h; CrCl <10: not defined
- HD: give usual dose q7 days, on dialysis days administer after dialysis; consider supplement if next maintenance dose not due right after dialysis; PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 10 mg
hepatitis B infection, chronic
- [12 yo and older]
- Dose: 10 mg PO qd; Info: use in combo with lamivudine, not as adefovir monotherapy if lamivudine resistant HBV
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [no adjustment]