sulfadiazine

Adult Dosing .

Dosage forms:  TAB: 500 mg

rheumatic fever prophylaxis, secondary

[1000 mg PO qd]

toxoplasmosis

[treatment, <60 kg]

Dose: 1000 mg PO q6h for at least 6wk; Info: give w/ pyrimethamine, leucovorin

[treatment, >60 kg]

Dose: 1500 mg PO q6h for at least 6wk; Info: give w/ pyrimethamine, leucovorin

[maintenance tx, <60 kg (off-label)]

Dose: 2000 mg/day PO divided bid-qid; Info: give w/ pyrimethamine, leucovorin

[maintenance tx, >60 kg (off-label)]

Dose: 4000 mg/day PO divided bid-qid; Info: give w/ pyrimethamine, leucovorin

renal dosing

[toxoplasmosis tx]

CrCl 10-50: 1000-1500 mg q12h; CrCl <10: 1000-1500 mg q24h

HD: 1000-1500 mg q24h, on dialysis days admin. after dialysis; supplement not defined; PD: not defined

[all other indications]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 500 mg

rheumatic fever prophylaxis, secondary

[2 mo and older, <30 kg]

Dose: 500 mg PO qd

[2 mo and older, >30 kg]

Dose: 1000 mg PO qd

toxoplasmosis

[treatment, congenital infection]

Dose: 100 mg/kg/day PO divided q12h x12mo; Info: give w/ pyrimethamine, leucovorin

[treatment, acquired infection]

Dose: 100-200 mg/kg/day PO divided q6h for at least 6wk; Max: 1000-1500 mg/dose; Info: give w/ pyrimethamine, leucovorin

[suppressive therapy]

Dose: 85-120 mg/kg/day PO divided q6-12h; Max: 2000-4000 g/day; Info: give w/ pyrimethamine, leucovorin

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised