fosamprenavir

Adult Dosing .

Dosage forms:  TAB: 700 mg

HIV infection

[tx-naive]

Dose: 1400 mg PO bid; Alt: 1400 mg PO qd with ritonavir 100-200 mg PO qd; 700 mg PO bid with ritonavir 100 mg PO bid; Info: not recommended per DHHS guidelines

[protease inhibitor-experienced]

Dose: 700 mg PO bid; Info: not recommended per DHHS guidelines; give with ritonavir 100 mg PO bid

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[tx-naive]

Child-Pugh score 5-6: 700 mg bid or 700 mg bid with ritonavir 100 mg qd; Child-Pugh score 7-9: 700 mg bid or 450 mg bid with ritonavir 100 mg qd; Child-Pugh score 10-15: 350 mg bid or 300 mg bid with ritonavir 100 mg qd

[protease inhibitor-experienced]

Child-Pugh score 5-6: 700 mg bid with ritonavir 100 mg qd; Child-Pugh score 7-9: 450 mg bid with ritonavir 100 mg qd; Child-Pugh score 10-15: 300 mg bid with ritonavir 100 mg qd

Peds Dosing .

Dosage forms:  TAB: 700 mg

HIV infection, protease inhibitor-naive

[>38 wk gestation, 4 wk old and older, >33 kg]

Dose: 18 mg/kg/dose up to 700 mg PO bid with ritonavir 100 mg PO bid; Info: not recommended per DHHS guidelines

HIV infection, protease inhibitor-experienced

[6 mo and older, >33 kg]

Dose: 18 mg/kg/dose up to 700 mg PO bid with ritonavir 100 mg PO bid; Info: not recommended per DHHS guidelines

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined, consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance