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bleomycin
generic
Black Box Warnings .
Appropriate Use
admin. only under supervision of physician experienced in cancer chemotherapy in adequate medical facility to manage complications
Pulmonary Toxicity
most severe drug-related toxicity; frequently presents as pneumonitis, occasionally progresses to pulmonary fibrosis; incr. incidence in elderly and at total doses >400 units, but also reported in young pts and at low doses
Idiosyncratic Reaction
severe rxn of hypotension, mental confusion, fever, rigors, and wheezing reported in 1% of lymphoma pts
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
squamous cell CA
- [10-20 units/m^2/dose IV/IM/SC 1-2x/wk]
- Max: cumulative dose 400 units; Alt: 0.25-0.5 units/kg/dose IV/IM/SC 1-2x/wk; Info: for head/neck, penis, cervix, or vulvar CA
Hodgkin lymphoma
- [10-20 units/m^2/dose IV/IM/SC 1-2x/wk]
- Start: <2 units IV/IM/SC x2 test doses; Max: cumulative dose 400 units; Alt: 0.25-0.5 units/kg/dose IV/IM/SC 1-2x/wk; Info: after 50% response give maint. dose 1 unit IV/IM qd or 5 units IV/IM qwk
non-Hodgkin lymphoma
- [10-20 units/m^2/dose IV/IM/SC 1-2x/wk]
- Start: <2 units IV/IM/SC x2 test doses; Max: cumulative dose 400 units; Alt: 0.25-0.5 units/kg/dose IV/IM/SC 1-2x/wk
testicular CA
- [10-20 units/m^2/dose IV/IM/SC 1-2x/wk]
- Max: cumulative dose 400 units; Alt: 0.25-0.5 units/kg/dose IV/IM/SC 1-2x/wk
pleural effusion, malignant
- [60 units intrapleurally x1]
- Info: for effusion tx and recurrence prevention
renal dosing
- [see below]
- CrCl 40-50: decr. usual dose by 30%; CrCl 30-40: decr. usual dose by 40%; CrCl 20-30: decr. usual dose by 45%; CrCl 10-20: decr. usual dose by 55%; CrCl 5-10: decr. usual dose by 60%
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.